Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender

Estibaliz Olano-Martin, Elizheeba Abraham, Rosalynn Gill-Garrison, Ana M. Valdes, Keith Grimaldi, Fiona Tang, Kim G. Jackson, Christine M. Williams, Anne M. Minihane

Research output: Contribution to journalArticle

Abstract

Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender × genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males.

Original languageEnglish
Pages (from-to)945-953
Number of pages9
JournalJournal of Lipid Research
Volume49
Issue number1
DOIs
Publication statusPublished - 1 Feb 2008

Keywords

  • polymorphism
  • gender
  • apoA-V gene variants
  • postprandial triglyceride

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