TY - JOUR
T1 - Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender
AU - Olano-Martin, Estibaliz
AU - Abraham, Elizheeba
AU - Gill-Garrison, Rosalynn
AU - Valdes, Ana M.
AU - Grimaldi, Keith
AU - Tang, Fiona
AU - Jackson, Kim G.
AU - Williams, Christine M.
AU - Minihane, Anne M.
N1 - <p>Originally published in: Journal of Lipid Research (2008), 49 (1), pp.945-953.</p>
PY - 2008/2/1
Y1 - 2008/2/1
N2 - Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender × genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males.
AB - Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender × genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males.
KW - polymorphism
KW - gender
KW - apoA-V gene variants
KW - postprandial triglyceride
U2 - 10.1194/jlr.M700112-JLR200
DO - 10.1194/jlr.M700112-JLR200
M3 - Article
VL - 49
SP - 945
EP - 953
JO - Journal of Lipid Research
JF - Journal of Lipid Research
SN - 0022-2275
IS - 1
ER -