Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender

Estibaliz Olano-Martin; Elizheeba Abraham; Rosalynn Gill-Garrison; Ana M. Valdes; Keith Grimaldi; Fiona Tang; Kim G. Jackson; Christine M. Williams; Anne M. Minihane

doi:10.1194/jlr.M700112-JLR200

Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender

Estibaliz Olano-Martin, Elizheeba Abraham, Rosalynn Gill-Garrison, Ana M. Valdes, Keith Grimaldi, Fiona Tang, Kim G. Jackson, Christine M. Williams, Anne M. Minihane

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Abstract

Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender × genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males.

Original language	English
Pages (from-to)	945-953
Number of pages	9
Journal	Journal of Lipid Research
Volume	49
Issue number	1
DOIs	https://doi.org/10.1194/jlr.M700112-JLR200
Publication status	Published - 1 Feb 2008

Keywords

polymorphism
gender
apoA-V gene variants
postprandial triglyceride

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10.1194/jlr.M700112-JLR200

Olano-Martin, E et al (2008) Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender
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Cite this

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title = "Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender",

abstract = "Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender × genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males.",

keywords = "polymorphism, gender, apoA-V gene variants, postprandial triglyceride",

author = "Estibaliz Olano-Martin and Elizheeba Abraham and Rosalynn Gill-Garrison and Valdes, {Ana M.} and Keith Grimaldi and Fiona Tang and Jackson, {Kim G.} and Williams, {Christine M.} and Minihane, {Anne M.}",

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TY - JOUR

T1 - Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender

AU - Olano-Martin, Estibaliz

AU - Abraham, Elizheeba

AU - Gill-Garrison, Rosalynn

AU - Valdes, Ana M.

AU - Grimaldi, Keith

AU - Tang, Fiona

AU - Jackson, Kim G.

AU - Williams, Christine M.

AU - Minihane, Anne M.

N1 - <p>Originally published in: Journal of Lipid Research (2008), 49 (1), pp.945-953.</p>

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender × genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males.

AB - Although apolipoprotein A-V (apoA-V) polymorphisms have been consistently associated with fasting triglyceride (TG) levels, their impact on postprandial lipemia remains relatively unknown. In this study, we investigate the impact of two common apoA-V polymorphisms (-1131 T>C and S19W) and apoA-V haplotypes on fasting and postprandial lipid metabolism in adults in the United Kingdom (n = 259). Compared with the wild-type TT, apoA-V -1131 TC heterozygotes had 15% (P = 0.057) and 21% (P = 0.002) higher fasting TG and postprandial TG area under the curve (AUC), respectively. Significant (P = 0.038) and nearly significant (P = 0.057) gender × genotype interactions were observed for fasting TG and TG AUC, with a greater impact of genotype in males.

KW - polymorphism

KW - gender

KW - apoA-V gene variants

KW - postprandial triglyceride

U2 - 10.1194/jlr.M700112-JLR200

DO - 10.1194/jlr.M700112-JLR200

M3 - Article

VL - 49

SP - 945

EP - 953

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

IS - 1

ER -

Influence of apoA-V gene variants on postprandial triglyceride metabolism: impact of gender

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Keywords

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