Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NO dependent pathways

Stephanie A. Robertson, Colin Rae, Annette Graham

Research output: Contribution to journalArticle

Abstract

Adipose tissue is a highly active endocrine organ, secreting bioactive molecules, adipokines, into the circulation. Obesity results in dysregulated adipokine secretion, contributing to pathophysiologies associated with this disorder, including insulin resistance and cardiovascular disease. The objective of this study was to establish whether resistin, a novel bioactive molecule produced by murine adipose tissue, and implicated in insulin resistance in rodents, can induce angiogenic responses in aortic tissues and endothelial cells in vitro, and to investigate the signal transduction pathways involved in these responses.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalRegulatory Peptides
Volume152
Issue number3-Jan
DOIs
Publication statusPublished - 1 Jan 2009

Keywords

  • diabetes
  • adiposity
  • obesity
  • angiogenesis

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