Implications of antimicrobial combinations in complex wound biofilms containing fungi

Eleanor M. Townsend, Leighann Sherry, Ryan Kean, Donald Hansom, William G. Mackay, Craig Williams, John Butcher, Gordon Ramage

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
87 Downloads (Pure)

Abstract

Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches influenced biofilm composition, this had no discernible effect on overall quantity. Only by combining bacterium- and fungus-specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.
Original languageEnglish
Pages (from-to)e00672
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number9
Early online date10 Jul 2017
DOIs
Publication statusPublished - Sep 2017

Keywords

  • antimicrobial agents
  • wound healing
  • biofilms
  • foot ulcers
  • Antimicrobial
  • Chronic wound
  • Candida
  • Biofilm
  • Polymicrobial
  • Biofilms/drug effects
  • Diabetic Foot/drug therapy
  • Humans
  • Candida albicans/drug effects
  • Ciprofloxacin/therapeutic use
  • Microbial Sensitivity Tests
  • Floxacillin/therapeutic use
  • Staphylococcus aureus/drug effects
  • Fluconazole/therapeutic use
  • Antifungal Agents/therapeutic use
  • Anti-Bacterial Agents/therapeutic use
  • Foot Ulcer/drug therapy
  • Pseudomonas aeruginosa/drug effects

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