Implications of antimicrobial combinations in complex wound biofilms containing fungi

Eleanor M. Townsend; Leighann Sherry; Ryan Kean; Donald Hansom; William G. Mackay; Craig Williams; John Butcher; Gordon Ramage

doi:10.1128/AAC.00672-17

Implications of antimicrobial combinations in complex wound biofilms containing fungi

Eleanor M. Townsend, Leighann Sherry, Ryan Kean, Donald Hansom, William G. Mackay, Craig Williams, John Butcher, Gordon Ramage

Biological and Biomedical Sciences

Research output: Contribution to journal › Article

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Abstract

Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while mono-treatment approaches influenced biofilm composition it had no discernible effect on overall quantity. Only by combining bacterial and fungal specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.

Original language	English
Pages (from-to)	e00672
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	9
Early online date	10 Jul 2017
DOIs	https://doi.org/10.1128/AAC.00672-17
Publication status	Published - Sep 2017

Keywords

antimicrobial agents
wound healing
biofilms
foot ulcers

Documents and Links

10.1128/AAC.00672-17

Townsend, E.M. et al (2017) Antimicrobial Agents and Chemotherapy article
This is the final author version of the article Townsend EM, Sherry L, Kean R, Hansom D, Mackay WG, Williams C, Butcher J, Ramage G. 2017. Implications of antimicrobial combinations in complex wound biofilms containing fungi. Antimicrob Agents Chemother 61:e00672-17. https://doi.org/10.1128/AAC.00672-17. Published by American Society for Microbiology. Copyright © 2017 American Society for Microbiology. All Rights Reserved.
Accepted author manuscript, 653 KB

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Cite this

Townsend, E. M., Sherry, L., Kean, R., Hansom, D., Mackay, W. G., Williams, C., Butcher, J., & Ramage, G. (2017). Implications of antimicrobial combinations in complex wound biofilms containing fungi. Antimicrobial Agents and Chemotherapy, 61(9), e00672. https://doi.org/10.1128/AAC.00672-17

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AU - Butcher, John

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