Abstract
Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches influenced biofilm composition, this had no discernible effect on overall quantity. Only by combining bacterium- and fungus-specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.
| Original language | English |
|---|---|
| Pages (from-to) | e00672 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 61 |
| Issue number | 9 |
| Early online date | 10 Jul 2017 |
| DOIs | |
| Publication status | Published - Sept 2017 |
| Externally published | Yes |
Keywords
- antimicrobial agents
- wound healing
- biofilms
- foot ulcers
- Antimicrobial
- Chronic wound
- Candida
- Biofilm
- Polymicrobial
- Biofilms/drug effects
- Diabetic Foot/drug therapy
- Humans
- Candida albicans/drug effects
- Ciprofloxacin/therapeutic use
- Microbial Sensitivity Tests
- Floxacillin/therapeutic use
- Staphylococcus aureus/drug effects
- Fluconazole/therapeutic use
- Antifungal Agents/therapeutic use
- Anti-Bacterial Agents/therapeutic use
- Foot Ulcer/drug therapy
- Pseudomonas aeruginosa/drug effects
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases
- Pharmacology
Documents and Links
- Townsend, E.M. et al (2017) Antimicrobial Agents and Chemotherapy article
This is the final author version of the article Townsend EM, Sherry L, Kean R, Hansom D, Mackay WG, Williams C, Butcher J, Ramage G. 2017. Implications of antimicrobial combinations in complex wound biofilms containing fungi. Antimicrob Agents Chemother 61:e00672-17. https://doi.org/10.1128/AAC.00672-17. Published by American Society for Microbiology. Copyright © 2017 American Society for Microbiology. All Rights Reserved.