Abstract
| Original language | English |
|---|---|
| Pages (from-to) | e00672 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 61 |
| Issue number | 9 |
| Early online date | 10 Jul 2017 |
| DOIs | |
| Publication status | Published - Sep 2017 |
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Keywords
- antimicrobial agents
- wound healing
- biofilms
- foot ulcers
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Implications of antimicrobial combinations in complex wound biofilms containing fungi. / Townsend, Eleanor M.; Sherry, Leighann; Kean, Ryan; Hansom, Donald; Mackay, William G.; Williams, Craig; Butcher, John; Ramage, Gordon.
In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 9, 09.2017, p. e00672.Research output: Contribution to journal › Article
TY - JOUR
T1 - Implications of antimicrobial combinations in complex wound biofilms containing fungi
AU - Townsend, Eleanor M.
AU - Sherry, Leighann
AU - Kean, Ryan
AU - Hansom, Donald
AU - Mackay, William G.
AU - Williams, Craig
AU - Butcher, John
AU - Ramage, Gordon
N1 - Acceptance date from journal webpage AAM requested with note of file deadline 5-10-17 6 month embargo (Romeo)
PY - 2017/9
Y1 - 2017/9
N2 - Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while mono-treatment approaches influenced biofilm composition it had no discernible effect on overall quantity. Only by combining bacterial and fungal specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.
AB - Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while mono-treatment approaches influenced biofilm composition it had no discernible effect on overall quantity. Only by combining bacterial and fungal specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.
KW - antimicrobial agents
KW - wound healing
KW - biofilms
KW - foot ulcers
U2 - 10.1128/AAC.00672-17
DO - 10.1128/AAC.00672-17
M3 - Article
VL - 61
SP - e00672
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 9
ER -