Impact of age and menopausal status on the postprandial triacylglycerol response in healthy women

Kim G. Jackson, Elizheeba Abraham, Adrian M. Smith, Peter Murray, Brendan O’Malley, Christine M. Williams, Anne M. Minihane

Research output: Contribution to journalArticle

Abstract

Thirty-seven premenopausal and sixty-one postmenopausal women underwent a sequential meal postprandial investigation, in which blood samples were taken at regular intervals after a test breakfast and lunch given at 0 and 330 min respectively. Lipids and glucose were measured in the fasting sample, with TAG analysed in the postprandial samples. Postmenopausal women were shown to have higher fasting total cholesterol, low density lipoprotein cholesterol (LDL-C) and glucose (P <0.02). Marked differences in the postprandial TAG response were evident between the groups, with a greater incremental area under the curve (IAUC) and maximum TAG concentration in the postmenopausal women (P <0.04). Multivariate regression analysis revealed both age and fasting TAG to be independently associated with the summary measures of the postprandial TAG response in the premenopausal women only.

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalAtherosclerosis
Volume208
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • postprandial triacylglycerol response
  • age
  • menopause
  • women

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    Jackson, K. G., Abraham, E., Smith, A. M., Murray, P., O’Malley, B., Williams, C. M., & Minihane, A. M. (2010). Impact of age and menopausal status on the postprandial triacylglycerol response in healthy women. Atherosclerosis, 208(1), 246-252. https://doi.org/10.1016/j.atherosclerosis.2009.06.030