Knee OA (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. Variations in aetiology, disease progression, clinical symptoms and treatment response have led to poor outcomes in some specific groups of patients. It has been hypothesized that these differences are due to the existence of underlying phenotypes or subgroups, which are characterized by different underlying mechanisms. Subgroup phenotyping is a new approach in KOA, with early explorative studies now emerging. However, a clear definition and characterisation of KOA phenotypes is still missing. The aim of this study is to identify the current evidence for the existence of distinct phenotypes in the KOA population.
- knee osteoarthritis
Dell'Isola, A., Allan, R., Smith, S., Marreiros, S. S. P., & Steultjens, M. (2016). Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature. Rheumatology, 55(Supplement 1), i137. https://doi.org/10.1093/rheumatology/kew137.004