Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella

Naushaba Nayeem; Fiona Kerr; Heike Naumann; Jackie Linehan; Simon Lovestone; Sebastian  Brandner

doi:10.1016/j.mcn.2006.11.014

Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella

Naushaba Nayeem, Fiona Kerr, Heike Naumann, Jackie Linehan, Simon Lovestone, Sebastian Brandner

Biological and Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN ablation in mice, but the underlying mechanism cannot be explained by the known role of PTEN in Akt/PKB inactivation. Here we show that the loss of PTEN in mouse cerebellar neurons causes neurodegeneration by hyperphosphorylation of tau and neurofilaments, and activation of Cdk5 and pERK1/2, suggesting that dysregulation of the PTEN/pAkt pathway can mediate neurodegeneration.

Original language	English
Pages (from-to)	400-408
Number of pages	9
Journal	Molecular and Cellular Neuroscience
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.mcn.2006.11.014
Publication status	Published - 5 Jan 2007

Keywords

tau phosphorylation
PTEN
Neurodegeneration

Documents and Links

10.1016/j.mcn.2006.11.014

Fingerprint Dive into the research topics of 'Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella'. Together they form a unique fingerprint.

Cite this

Nayeem, N., Kerr, F., Naumann, H., Linehan, J., Lovestone, S., & Brandner, S. (2007). Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella. Molecular and Cellular Neuroscience, 34(3), 400-408. https://doi.org/10.1016/j.mcn.2006.11.014

@article{8163051494e241ae97c514d7fe344970,

title = "Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella",

abstract = "Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN ablation in mice, but the underlying mechanism cannot be explained by the known role of PTEN in Akt/PKB inactivation. Here we show that the loss of PTEN in mouse cerebellar neurons causes neurodegeneration by hyperphosphorylation of tau and neurofilaments, and activation of Cdk5 and pERK1/2, suggesting that dysregulation of the PTEN/pAkt pathway can mediate neurodegeneration.",

keywords = "tau phosphorylation, PTEN, Neurodegeneration",

author = "Naushaba Nayeem and Fiona Kerr and Heike Naumann and Jackie Linehan and Simon Lovestone and Sebastian Brandner",

year = "2007",

month = jan,

day = "5",

doi = "10.1016/j.mcn.2006.11.014",

language = "English",

volume = "34",

pages = "400--408",

journal = "Molecular and Cellular Neuroscience",

issn = "1044-7431",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella

AU - Nayeem, Naushaba

AU - Kerr, Fiona

AU - Naumann, Heike

AU - Linehan, Jackie

AU - Lovestone, Simon

AU - Brandner, Sebastian

PY - 2007/1/5

Y1 - 2007/1/5

N2 - Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN ablation in mice, but the underlying mechanism cannot be explained by the known role of PTEN in Akt/PKB inactivation. Here we show that the loss of PTEN in mouse cerebellar neurons causes neurodegeneration by hyperphosphorylation of tau and neurofilaments, and activation of Cdk5 and pERK1/2, suggesting that dysregulation of the PTEN/pAkt pathway can mediate neurodegeneration.

AB - Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN ablation in mice, but the underlying mechanism cannot be explained by the known role of PTEN in Akt/PKB inactivation. Here we show that the loss of PTEN in mouse cerebellar neurons causes neurodegeneration by hyperphosphorylation of tau and neurofilaments, and activation of Cdk5 and pERK1/2, suggesting that dysregulation of the PTEN/pAkt pathway can mediate neurodegeneration.

KW - tau phosphorylation

KW - PTEN

KW - Neurodegeneration

U2 - 10.1016/j.mcn.2006.11.014

DO - 10.1016/j.mcn.2006.11.014

M3 - Article

VL - 34

SP - 400

EP - 408

JO - Molecular and Cellular Neuroscience

JF - Molecular and Cellular Neuroscience

SN - 1044-7431

IS - 3

ER -