Abstract
Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN ablation in mice, but the underlying mechanism cannot be explained by the known role of PTEN in Akt/PKB inactivation. Here we show that the loss of PTEN in mouse cerebellar neurons causes neurodegeneration by hyperphosphorylation of tau and neurofilaments, and activation of Cdk5 and pERK1/2, suggesting that dysregulation of the PTEN/pAkt pathway can mediate neurodegeneration.
Original language | English |
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Pages (from-to) | 400-408 |
Number of pages | 9 |
Journal | Molecular and Cellular Neuroscience |
Volume | 34 |
Issue number | 3 |
DOIs | |
Publication status | Published - 5 Jan 2007 |
Keywords
- tau phosphorylation
- PTEN
- Neurodegeneration