Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella

Naushaba Nayeem, Fiona Kerr, Heike Naumann, Jackie Linehan, Simon Lovestone, Sebastian Brandner

Research output: Contribution to journalArticle

Abstract

Inherited mutations to the tumor suppressor PTEN sporadically lead to cerebellar gangliocytoma characterized by migration defects. This has been modeled by CNS-specific PTEN ablation in mice, but the underlying mechanism cannot be explained by the known role of PTEN in Akt/PKB inactivation. Here we show that the loss of PTEN in mouse cerebellar neurons causes neurodegeneration by hyperphosphorylation of tau and neurofilaments, and activation of Cdk5 and pERK1/2, suggesting that dysregulation of the PTEN/pAkt pathway can mediate neurodegeneration.
Original languageEnglish
Pages (from-to)400-408
Number of pages9
JournalMolecular and Cellular Neuroscience
Volume34
Issue number3
DOIs
Publication statusPublished - 5 Jan 2007

Keywords

  • tau phosphorylation
  • PTEN
  • Neurodegeneration

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