How does light intensity physical activity associate with adult cardiometabolic health and mortality? Systematic review with meta-analysis of experimental and observational studies

Sebastien F.M. Chastin, Marieke De Craemer , Katrien De Cocker , Lauren Powell, Jelle Van Cauwenberg, Philippa Dall, Mark Hamer, Emmanuel Stamatakis

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Abstract

Aim To assess the relationship between time spent in light physical activity and cardiometabolic health and mortality in adults. Design Systematic review and meta-analysis.Data sources Searches in Medline, Embase, PsycInfo, CINAHL, and three rounds of hand searches. Eligibility criteria for selecting studies Experimental (including acute mechanistic studies and physical activity intervention programme) and observational studies (excluding case and case control studies) conducted in adults(aged =18yrs) published in English before February 2018 and reporting on the relationship between light physical activity (< 3 METs) and cardiometabolic health outcomes or all-cause mortality.Study appraisal and synthesis Study quality appraisal with Qualsyst tool and random effects inverse variance meta-analysis.Results Seventy two studies were eligible including 27 experimental studies (and 45 observational studies. Mechanistic experimental studies showed that short but frequent bouts of light intensity activity throughout the day reduced post-prandial glucose (-17.5% CI [-26.2, 49 -8.7]) and insulin (-25.1% [-31.8 -18.3]) levels compared to continuous sitting, but there was very limited evidence for it affecting other cardiometabolic markers including mortality. Three light physical activity programme intervention studies (n ranging from 12 to 58) reduced adiposity, improved blood pressure and lipidaemia; the programmes consisted of activity of > 150 min/week for at least 12 weeks. Six out of eight prospective observational studies that were entered in the meta-analysis reported that more time spent in daily light activity reduced risk of all-cause mortality (pooled HR 0.71 CI [0.62 0.83]).Conclusions Light intensity physical activity could play a role in improving adult cardiometabolic health and reducing mortality risk. Frequent short bouts of light activity improve glycaemic control. Nevertheless, the modest volume of the prospective epidemiological evidence base and the moderate consistency between observational and laboratory evidence inhibits definitive conclusions.
Original languageEnglish
JournalBritish Journal of Sports Medicine
DOIs
Publication statusPublished - 25 Apr 2018

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Observational Studies
Meta-Analysis
Light
Mortality
Health
Information Storage and Retrieval
Case-Control Studies
Prospective Studies

Keywords

  • inactivity, sedentary behaviour, cardiovascular disease, diabetes, obesity
  • light intensity activity, physical activity

Cite this

@article{68dad27df6ce4235a5504ce4a76ca39f,
title = "How does light intensity physical activity associate with adult cardiometabolic health and mortality? Systematic review with meta-analysis of experimental and observational studies",
abstract = "Aim To assess the relationship between time spent in light physical activity and cardiometabolic health and mortality in adults. Design Systematic review and meta-analysis.Data sources Searches in Medline, Embase, PsycInfo, CINAHL, and three rounds of hand searches. Eligibility criteria for selecting studies Experimental (including acute mechanistic studies and physical activity intervention programme) and observational studies (excluding case and case control studies) conducted in adults(aged =18yrs) published in English before February 2018 and reporting on the relationship between light physical activity (< 3 METs) and cardiometabolic health outcomes or all-cause mortality.Study appraisal and synthesis Study quality appraisal with Qualsyst tool and random effects inverse variance meta-analysis.Results Seventy two studies were eligible including 27 experimental studies (and 45 observational studies. Mechanistic experimental studies showed that short but frequent bouts of light intensity activity throughout the day reduced post-prandial glucose (-17.5{\%} CI [-26.2, 49 -8.7]) and insulin (-25.1{\%} [-31.8 -18.3]) levels compared to continuous sitting, but there was very limited evidence for it affecting other cardiometabolic markers including mortality. Three light physical activity programme intervention studies (n ranging from 12 to 58) reduced adiposity, improved blood pressure and lipidaemia; the programmes consisted of activity of > 150 min/week for at least 12 weeks. Six out of eight prospective observational studies that were entered in the meta-analysis reported that more time spent in daily light activity reduced risk of all-cause mortality (pooled HR 0.71 CI [0.62 0.83]).Conclusions Light intensity physical activity could play a role in improving adult cardiometabolic health and reducing mortality risk. Frequent short bouts of light activity improve glycaemic control. Nevertheless, the modest volume of the prospective epidemiological evidence base and the moderate consistency between observational and laboratory evidence inhibits definitive conclusions.",
keywords = "inactivity, sedentary behaviour, cardiovascular disease, diabetes, obesity, light intensity activity, physical activity",
author = "Chastin, {Sebastien F.M.} and {De Craemer}, Marieke and {De Cocker}, Katrien and Lauren Powell and {Van Cauwenberg}, Jelle and Philippa Dall and Mark Hamer and Emmanuel Stamatakis",
note = "Acceptance in SAN Funding: the authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors. OA article",
year = "2018",
month = "4",
day = "25",
doi = "10.1136/bjsports-2017-097563",
language = "English",
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issn = "0306-3674",
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How does light intensity physical activity associate with adult cardiometabolic health and mortality? Systematic review with meta-analysis of experimental and observational studies. / Chastin, Sebastien F.M.; De Craemer , Marieke; De Cocker , Katrien; Powell, Lauren; Van Cauwenberg, Jelle; Dall, Philippa; Hamer, Mark; Stamatakis, Emmanuel.

In: British Journal of Sports Medicine, 25.04.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - How does light intensity physical activity associate with adult cardiometabolic health and mortality? Systematic review with meta-analysis of experimental and observational studies

AU - Chastin, Sebastien F.M.

AU - De Craemer , Marieke

AU - De Cocker , Katrien

AU - Powell, Lauren

AU - Van Cauwenberg, Jelle

AU - Dall, Philippa

AU - Hamer, Mark

AU - Stamatakis, Emmanuel

N1 - Acceptance in SAN Funding: the authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors. OA article

PY - 2018/4/25

Y1 - 2018/4/25

N2 - Aim To assess the relationship between time spent in light physical activity and cardiometabolic health and mortality in adults. Design Systematic review and meta-analysis.Data sources Searches in Medline, Embase, PsycInfo, CINAHL, and three rounds of hand searches. Eligibility criteria for selecting studies Experimental (including acute mechanistic studies and physical activity intervention programme) and observational studies (excluding case and case control studies) conducted in adults(aged =18yrs) published in English before February 2018 and reporting on the relationship between light physical activity (< 3 METs) and cardiometabolic health outcomes or all-cause mortality.Study appraisal and synthesis Study quality appraisal with Qualsyst tool and random effects inverse variance meta-analysis.Results Seventy two studies were eligible including 27 experimental studies (and 45 observational studies. Mechanistic experimental studies showed that short but frequent bouts of light intensity activity throughout the day reduced post-prandial glucose (-17.5% CI [-26.2, 49 -8.7]) and insulin (-25.1% [-31.8 -18.3]) levels compared to continuous sitting, but there was very limited evidence for it affecting other cardiometabolic markers including mortality. Three light physical activity programme intervention studies (n ranging from 12 to 58) reduced adiposity, improved blood pressure and lipidaemia; the programmes consisted of activity of > 150 min/week for at least 12 weeks. Six out of eight prospective observational studies that were entered in the meta-analysis reported that more time spent in daily light activity reduced risk of all-cause mortality (pooled HR 0.71 CI [0.62 0.83]).Conclusions Light intensity physical activity could play a role in improving adult cardiometabolic health and reducing mortality risk. Frequent short bouts of light activity improve glycaemic control. Nevertheless, the modest volume of the prospective epidemiological evidence base and the moderate consistency between observational and laboratory evidence inhibits definitive conclusions.

AB - Aim To assess the relationship between time spent in light physical activity and cardiometabolic health and mortality in adults. Design Systematic review and meta-analysis.Data sources Searches in Medline, Embase, PsycInfo, CINAHL, and three rounds of hand searches. Eligibility criteria for selecting studies Experimental (including acute mechanistic studies and physical activity intervention programme) and observational studies (excluding case and case control studies) conducted in adults(aged =18yrs) published in English before February 2018 and reporting on the relationship between light physical activity (< 3 METs) and cardiometabolic health outcomes or all-cause mortality.Study appraisal and synthesis Study quality appraisal with Qualsyst tool and random effects inverse variance meta-analysis.Results Seventy two studies were eligible including 27 experimental studies (and 45 observational studies. Mechanistic experimental studies showed that short but frequent bouts of light intensity activity throughout the day reduced post-prandial glucose (-17.5% CI [-26.2, 49 -8.7]) and insulin (-25.1% [-31.8 -18.3]) levels compared to continuous sitting, but there was very limited evidence for it affecting other cardiometabolic markers including mortality. Three light physical activity programme intervention studies (n ranging from 12 to 58) reduced adiposity, improved blood pressure and lipidaemia; the programmes consisted of activity of > 150 min/week for at least 12 weeks. Six out of eight prospective observational studies that were entered in the meta-analysis reported that more time spent in daily light activity reduced risk of all-cause mortality (pooled HR 0.71 CI [0.62 0.83]).Conclusions Light intensity physical activity could play a role in improving adult cardiometabolic health and reducing mortality risk. Frequent short bouts of light activity improve glycaemic control. Nevertheless, the modest volume of the prospective epidemiological evidence base and the moderate consistency between observational and laboratory evidence inhibits definitive conclusions.

KW - inactivity, sedentary behaviour, cardiovascular disease, diabetes, obesity

KW - light intensity activity, physical activity

U2 - 10.1136/bjsports-2017-097563

DO - 10.1136/bjsports-2017-097563

M3 - Article

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

SN - 0306-3674

ER -