@article{08ec05d30e4a438b9aff7f5aa83bb1ec,
title = "HIV-1 subtype dynamics over 10 years in a rural Ugandan cohort",
abstract = "Our objective was to monitor changes in the subtypes of HIV-1 infecting a rural Ugandan cohort where the spread of HIV-1 is by unprotected heterosexual contact and subtypes A and D predominate. Should one subtype be better able to spread we would anticipate a rise in incidence of one subtype at the expense of the other over a decade of study. We employed a natural history cohort, which had been established by the Medical Research Council in 1990 and subtyped virus from 90% (139) incident cases by DNA sequencing in two separate genes. We found that viral subtype had no predilection for males, females or age at infection and that between 1990 and 2000 there was no significant change in the relative number of different subtypes. The only significant trend was a reduction in the proportion of viruses classified as recombinant. This may reflect the overall decline in prevalence of HIV-1 in Uganda over this period.",
keywords = "Heterosexual transmission, HIV-1 subtypes, Molecular biology, Recombination, Uganda",
author = "Yirrell, {David L.} and Pontiano Kaleebu and Dilys Morgan and Sharon Hutchinson and Whitworth, {James A.}",
note = "Funding Information: Yirrell David L MRC Programme on AIDS in Uganda, UVRI, PO Box 49, Entebbe, Uganda; Centre for HIV Research, University of Edinburgh, West Mains Road, Edinburgh EH9 3JN; and Department of Public Health, University of Glasgow G12 8RZ, UK Kaleebu Pontiano MRC Programme on AIDS in Uganda, UVRI, PO Box 49, Entebbe, Uganda Morgan Dilys MRC Programme on AIDS in Uganda, UVRI, PO Box 49, Entebbe, Uganda Hutchinson Sharon Scottish Centre for Infection and Environmental Health, Glasgow G3 7LN; and Department of Public Health, University of Glasgow G12 8RZ, UK Whitworth James A MRC Programme on AIDS in Uganda, UVRI, PO Box 49, Entebbe, Uganda 01 02 2004 15 2 103 106 {\textcopyright} Royal Society of Medicine Press Limited 2004 2004 Our objective was to monitor changes in the subtypes of HIV-1 infecting a rural Ugandan cohort where the spread of HIV-1 is by unprotected heterosexual contact and subtypes A and D predominate. Should one subtype be better able to spread we would anticipate a rise in incidence of one subtype at the expense of the other over a decade of study. We employed a natural history cohort, which had been established by the Medical Research Council in 1990 and subtyped virus from 90% (139) incident cases by DNA sequencing in two separate genes. We found that viral subtype had no predilection for males, females or age at infection and that between 1990 and 2000 there was no significant change in the relative number of different subtypes. The only significant trend was a reduction in the proportion of viruses classified as recombinant. This may reflect the overall decline in prevalence of HIV-1 in Uganda over this period. HIV-1 SUBTYPES UGANDA RECOMBINATION HETEROSEXUAL TRANSMISSION MOLECULAR BIOLOGY ",
year = "2004",
month = feb,
doi = "10.1258/095646204322764299",
language = "English",
volume = "15",
pages = "103--106",
journal = "International Journal of STD and AIDS",
issn = "0956-4624",
publisher = "SAGE Publications Ltd",
number = "2",
}