Higher intraocular pressure is associated with slower axial growth in children with non-pathological high myopia

Fabian Sl Yii, Mingguang He, Francesca Chappell, Miguel Bernabeu, Tom MacGillvray, Baljean Dillon, Andrew Tatham, Niall Strang

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
46 Downloads (Pure)

Abstract

Objectives
To investigate the association between intraocular pressure (IOP) and axial elongation rate in highly myopic children from the ZOC-BHVI High Myopia Cohort Study.

Methods
162 eyes of 81 healthy children (baseline spherical equivalent: −6.25 D to −15.50 D) aged 7–12 years with non-pathological high myopia were studied over five biennial visits. The mean (SD) follow-up duration was 5.2 (3.3) years. A linear mixed-effects model (LMM) was used to assess the association between IOP (at time point t−1) and axial elongation rate (annual rate of change in AL from t−1 to t), controlling for a pre-defined set of covariates including sex, age, central corneal thickness, anterior chamber depth and lens thickness (at t−1). LMM was also used to assess the contemporaneous association between IOP and axial length (AL) at t, controlling for the same set of covariates (at t) as before.

Results
Higher IOP was associated with slower axial growth (β = −0.01, 95% CI −0.02 to −0.005, p = 0.001). There was a positive contemporaneous association between IOP and AL (β = 0.03, 95% CI 0.01–0.05, p = 0.004), but this association became progressively less positive with increasing age, as indicated by a negative interaction effect between IOP and age on AL (β = −0.01, 95% CI −0.01 to −0.003, p = 0.001).

Conclusions
Higher IOP is associated with slower rather than faster axial growth in children with non-pathological high myopia, an association plausibly confounded by the increased influence of ocular compliance on IOP.
Original languageEnglish
Pages (from-to)1208-1214
Number of pages7
JournalEye
Volume38
Issue number6
Early online date11 Dec 2023
DOIs
Publication statusPublished - Apr 2024

ASJC Scopus subject areas

  • Sensory Systems
  • Ophthalmology

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