Anti-HEV IgG seroprevalence and incidence of hepatitis E varies both between and within countries, and over time. For example, in south-west (SW) France, one study has found a seroprevalence of 52% and incidence of hepatitis E of 3% . Although HEV appears to be hyperendemic in SW France, seroprevalence varies considerably between French departments (range: 8–86%) . The reason for this observation is unknown, but could be related to geographical differences in dietary habits. In contrast, seroprevalence in Scotland, first assessed for the period 2004–08, was found to be 4.7% . In recent years the number of cases of hepatitis E documented in many European countries, including Scotland, has increased, mostly due to improved testing and case ascertainment. However, there is evidence that points to a recent genuine increase in incidence in some European countries [6,12-16].
Compared with many European countries, previously reported Scottish seroprevalence data and rates of viraemia in blood donors were low . In an earlier study, donors were sampled during 2004–08 and were mainly from the Edinburgh area. However, figures for the rest of Scotland and recent changes in seroprevalence and numbers of viraemic blood donors are unknown. The aims of this study were to determine the recent seroprevalence in differing geographical areas of Scotland and if there has been a change in recent years and to cross reference this with the current numbers of viraemic donors and laboratory-confirmed cases, including those in the Scottish liver transplant population.
|Number of pages||10|
|Publication status||Published - 22 Mar 2018|
- hepatitis E