Hepatitis C reinfection following treatment induced viral clearance among people who have injected drugs

Amanda Weir, Allan McLeod, Hamish Innes, Heather Valerio, Esther Aspinall, David Goldberg, Stephen Barclay, John Dillon, Ray Fox, Andrew Fraser, Peter Hayes, Nicholas Kennedy, Peter Mills, Adrian Stanley, Celia Aitken, Rory Gunson, Kate Templeton, Alison Hunt, Paul McIntyre, Sharon Hutchinson

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Abstract

Although people who inject drugs (PWID) are an important group to receive Hepatitis C Virus (HCV) antiviral therapy, initiation onto treatment remains low. Concerns over reinfection may make clinicians reluctant to treat this group. We examined the risk of HCV reinfection among a cohort of PWID (encompassing all those reporting a history of injecting drug use) from Scotland who achieved a sustained virological response (SVR). Clinical and laboratory data were used to monitor RNA testing among PWID who attained SVR following therapy between 2000 and 2009. Data were linked to morbidity and mortality records. Follow-up began one year after completion of therapy, ending on 31st December, 2012. Frequency of RNA testing during follow-up was calculated and the incidence of HCV reinfection estimated. Cox proportional hazards regression was used to examine factors associated with HCV reinfection.
Original languageEnglish
Pages (from-to)53–60
Number of pages8
JournalDrug and Alcohol Dependence
Volume165
Early online date28 May 2016
DOIs
Publication statusPublished - Aug 2016

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Keywords

  • Hepatitis C
  • virology

Cite this

Weir, A., McLeod, A., Innes, H., Valerio, H., Aspinall, E., Goldberg, D., Barclay, S., Dillon, J., Fox, R., Fraser, A., Hayes, P., Kennedy, N., Mills, P., Stanley, A., Aitken, C., Gunson, R., Templeton, K., Hunt, A., McIntyre, P., & Hutchinson, S. (2016). Hepatitis C reinfection following treatment induced viral clearance among people who have injected drugs. Drug and Alcohol Dependence, 165, 53–60. https://doi.org/10.1016/j.drugalcdep.2016.05.012