Hepatitis C reinfection following treatment induced viral clearance among people who have injected drugs

Amanda Weir, Allan McLeod, Hamish Innes, Heather Valerio, Esther Aspinall, David Goldberg, Stephen Barclay, John Dillon, Ray Fox, Andrew Fraser, Peter Hayes, Nicholas Kennedy, Peter Mills, Adrian Stanley, Celia Aitken, Rory Gunson, Kate Templeton, Alison Hunt, Paul McIntyre, Sharon Hutchinson

Research output: Contribution to journalArticle

123 Downloads (Pure)

Abstract

Although people who inject drugs (PWID) are an important group to receive Hepatitis C Virus (HCV) antiviral therapy, initiation onto treatment remains low. Concerns over reinfection may make clinicians reluctant to treat this group. We examined the risk of HCV reinfection among a cohort of PWID (encompassing all those reporting a history of injecting drug use) from Scotland who achieved a sustained virological response (SVR). Clinical and laboratory data were used to monitor RNA testing among PWID who attained SVR following therapy between 2000 and 2009. Data were linked to morbidity and mortality records. Follow-up began one year after completion of therapy, ending on 31st December, 2012. Frequency of RNA testing during follow-up was calculated and the incidence of HCV reinfection estimated. Cox proportional hazards regression was used to examine factors associated with HCV reinfection.
Original languageEnglish
Pages (from-to)53–60
Number of pages8
JournalDrug and Alcohol Dependence
Volume165
Early online date28 May 2016
DOIs
Publication statusPublished - Aug 2016

Fingerprint

Hepatitis C
Viruses
Hepacivirus
Pharmaceutical Preparations
RNA
Scotland
Testing
Antiviral Agents
Hazards
Therapeutics
Morbidity
Mortality
Incidence

Keywords

  • Hepatitis C
  • virology

Cite this

Weir, Amanda ; McLeod, Allan ; Innes, Hamish ; Valerio, Heather ; Aspinall, Esther ; Goldberg, David ; Barclay, Stephen ; Dillon, John ; Fox, Ray ; Fraser, Andrew ; Hayes, Peter ; Kennedy, Nicholas ; Mills, Peter ; Stanley, Adrian ; Aitken, Celia ; Gunson, Rory ; Templeton, Kate ; Hunt, Alison ; McIntyre, Paul ; Hutchinson, Sharon. / Hepatitis C reinfection following treatment induced viral clearance among people who have injected drugs. In: Drug and Alcohol Dependence. 2016 ; Vol. 165. pp. 53–60.
@article{e2445a8be69d409abee840a2cb609331,
title = "Hepatitis C reinfection following treatment induced viral clearance among people who have injected drugs",
abstract = "Although people who inject drugs (PWID) are an important group to receive Hepatitis C Virus (HCV) antiviral therapy, initiation onto treatment remains low. Concerns over reinfection may make clinicians reluctant to treat this group. We examined the risk of HCV reinfection among a cohort of PWID (encompassing all those reporting a history of injecting drug use) from Scotland who achieved a sustained virological response (SVR). Clinical and laboratory data were used to monitor RNA testing among PWID who attained SVR following therapy between 2000 and 2009. Data were linked to morbidity and mortality records. Follow-up began one year after completion of therapy, ending on 31st December, 2012. Frequency of RNA testing during follow-up was calculated and the incidence of HCV reinfection estimated. Cox proportional hazards regression was used to examine factors associated with HCV reinfection.",
keywords = "Hepatitis C, virology",
author = "Amanda Weir and Allan McLeod and Hamish Innes and Heather Valerio and Esther Aspinall and David Goldberg and Stephen Barclay and John Dillon and Ray Fox and Andrew Fraser and Peter Hayes and Nicholas Kennedy and Peter Mills and Adrian Stanley and Celia Aitken and Rory Gunson and Kate Templeton and Alison Hunt and Paul McIntyre and Sharon Hutchinson",
note = "online pub: 28/05/2016 accepted: 17/5/16 (proof in SAN) AAM uploaded: 9-6-16, embargo 12m ET 25-7-16",
year = "2016",
month = "8",
doi = "10.1016/j.drugalcdep.2016.05.012",
language = "English",
volume = "165",
pages = "53–60",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "Elsevier Ireland Ltd",

}

Weir, A, McLeod, A, Innes, H, Valerio, H, Aspinall, E, Goldberg, D, Barclay, S, Dillon, J, Fox, R, Fraser, A, Hayes, P, Kennedy, N, Mills, P, Stanley, A, Aitken, C, Gunson, R, Templeton, K, Hunt, A, McIntyre, P & Hutchinson, S 2016, 'Hepatitis C reinfection following treatment induced viral clearance among people who have injected drugs', Drug and Alcohol Dependence, vol. 165, pp. 53–60. https://doi.org/10.1016/j.drugalcdep.2016.05.012

Hepatitis C reinfection following treatment induced viral clearance among people who have injected drugs. / Weir, Amanda; McLeod, Allan; Innes, Hamish; Valerio, Heather; Aspinall, Esther; Goldberg, David; Barclay, Stephen; Dillon, John; Fox, Ray; Fraser, Andrew; Hayes, Peter; Kennedy, Nicholas; Mills, Peter; Stanley, Adrian; Aitken, Celia; Gunson, Rory; Templeton, Kate; Hunt, Alison; McIntyre, Paul; Hutchinson, Sharon.

In: Drug and Alcohol Dependence, Vol. 165, 08.2016, p. 53–60.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hepatitis C reinfection following treatment induced viral clearance among people who have injected drugs

AU - Weir, Amanda

AU - McLeod, Allan

AU - Innes, Hamish

AU - Valerio, Heather

AU - Aspinall, Esther

AU - Goldberg, David

AU - Barclay, Stephen

AU - Dillon, John

AU - Fox, Ray

AU - Fraser, Andrew

AU - Hayes, Peter

AU - Kennedy, Nicholas

AU - Mills, Peter

AU - Stanley, Adrian

AU - Aitken, Celia

AU - Gunson, Rory

AU - Templeton, Kate

AU - Hunt, Alison

AU - McIntyre, Paul

AU - Hutchinson, Sharon

N1 - online pub: 28/05/2016 accepted: 17/5/16 (proof in SAN) AAM uploaded: 9-6-16, embargo 12m ET 25-7-16

PY - 2016/8

Y1 - 2016/8

N2 - Although people who inject drugs (PWID) are an important group to receive Hepatitis C Virus (HCV) antiviral therapy, initiation onto treatment remains low. Concerns over reinfection may make clinicians reluctant to treat this group. We examined the risk of HCV reinfection among a cohort of PWID (encompassing all those reporting a history of injecting drug use) from Scotland who achieved a sustained virological response (SVR). Clinical and laboratory data were used to monitor RNA testing among PWID who attained SVR following therapy between 2000 and 2009. Data were linked to morbidity and mortality records. Follow-up began one year after completion of therapy, ending on 31st December, 2012. Frequency of RNA testing during follow-up was calculated and the incidence of HCV reinfection estimated. Cox proportional hazards regression was used to examine factors associated with HCV reinfection.

AB - Although people who inject drugs (PWID) are an important group to receive Hepatitis C Virus (HCV) antiviral therapy, initiation onto treatment remains low. Concerns over reinfection may make clinicians reluctant to treat this group. We examined the risk of HCV reinfection among a cohort of PWID (encompassing all those reporting a history of injecting drug use) from Scotland who achieved a sustained virological response (SVR). Clinical and laboratory data were used to monitor RNA testing among PWID who attained SVR following therapy between 2000 and 2009. Data were linked to morbidity and mortality records. Follow-up began one year after completion of therapy, ending on 31st December, 2012. Frequency of RNA testing during follow-up was calculated and the incidence of HCV reinfection estimated. Cox proportional hazards regression was used to examine factors associated with HCV reinfection.

KW - Hepatitis C

KW - virology

U2 - 10.1016/j.drugalcdep.2016.05.012

DO - 10.1016/j.drugalcdep.2016.05.012

M3 - Article

VL - 165

SP - 53

EP - 60

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

ER -