HCV epidemiology in high-risk groups and the risk of reinfection

Havard Midgard, Amanda Weir, Norah Palmateer, Vincent Lo Re III, Juan A. Pineda, Juan Macias, Olav Dalgard

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Injecting risk behaviours among people who inject drugs (PWID) and high-risk sexual practices among men who have sex with men (MSM) are important routes of hepatitis C virus (HCV) transmission. Current direct-acting antiviral treatment offers unique opportunities for reductions in HCV-related liver disease burden and epidemic control in high-risk groups, but these prospects could be counteracted by HCV reinfection due to on-going risk behaviours after successful treatment. Based on existing data from small and heterogeneous studies of interferon-based treatment, the incidence of reinfection after sustained virological response range from 2–6/100 person years among PWID to 10–15/100 person years among human immunodeficiency virus-infected MSM. These differences mainly reflect heterogeneity in study populations with regards to risk behaviours, but also reflect variations in study designs and applied virological methods.
Original languageEnglish
Pages (from-to)S33–S45
Number of pages13
JournalJournal of Hepatology
Issue number1 (Supplement)
Early online date30 Sep 2016
Publication statusPublished - Oct 2016


  • HCV
  • hepatitis C
  • reinfection
  • virology

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