Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease

Abdul Hye, Fiona Kerr, Nicola Archer, Catherine Foy, Michaela Poppe, Richard Brown, Gillian Hamilton, John Powell, Brian Anderton, Simon Lovestone

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109 Citations (Scopus)


Alzheimer's disease (AD) is a disorder without a molecular marker in peripheral tissues or a disease modifying treatment. As increasing evidence has suggested a role for glycogen synthase kinase-3 (GSK-3) in the pathogenesis of the condition we measured total GSK-3 protein (alpha and beta isoforms) and GSK-3 activity (serine 9 phosphorylation) in a group of healthy elderly people, in AD and in mild cognitive impairment (MCI). Total GSK-3 protein was increased in both AD and in MCI without a compensatory decrease in activity. These data suggest that GSK-3 assays might be a useful diagnostic marker in a readily available tissue and moreover that GSK-3 activity is increased in the prodromal phase of the disorder suggesting that inhibition of GSK-3 might be a useful therapeutic strategy.
Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 13 Dec 2004


  • Alzheimer’s disease
  • glycogen synthase kinase-3
  • GCK-3
  • biomarker
  • lymphocytes
  • white cells
  • mild cognitive impairment
  • MCI


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