Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes

Eri Takematsu, Adrianne Spencer, Jeff Auster, Po-Chih Chen, Annette Graham, Patricia Martin, Aaron B Baker*

*Corresponding author for this work

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Non-healing chronic ulcers are a serious complication of diabetes and are a major healthcare problem. While a host of treatments have been explored to heal or prevent these ulcers from forming, these treatments have not been found to be consistently effective in clinical trials. An understanding of the changes in gene expression in the skin of diabetic patients may provide insight into the processes and mechanisms that precede the formation of non-healing ulcers. In this study, we investigated genome wide changes in gene expression in skin between patients with type 2 diabetes and non-diabetic patients using next generation sequencing. We compared the gene expression in skin samples taken from 27 patients (13 with type 2 diabetes and 14 non-diabetic). This information may be useful in identifying the causal factors and potential therapeutic targets for the prevention and treatment of diabetic related diseases.
Original languageEnglish
Article numbere0225267
Number of pages22
JournalPLoS ONE
Issue number2
Publication statusPublished - 21 Feb 2020



  • type 2 diabetes
  • ulcers
  • gene expression
  • sequencing

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