Galanin is a modulator of eccrine sweat gland secretion

Douglas Bovell; Barbara S.  Holub; Olutayo  Odusanwo; Bernhard  Brodowicz; Isabella  Rauch; Barbara Kofler; Roland Lang

doi:10.1111/exd.12067

Galanin is a modulator of eccrine sweat gland secretion

Douglas Bovell, Barbara S. Holub, Olutayo Odusanwo, Bernhard Brodowicz, Isabella Rauch, Barbara Kofler, Roland Lang

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Abstract

The neuropeptide galanin has been ascribed different roles in modulating physiological functions in the skin. The present study examined the function of galanin in eccrine sweat gland physiology. We demonstrated secretion of galanin by sweat glands in vivo by radioimmunoassay of human sweat (20-192 fmol galanin/ml). Furthermore, human sweat glands expressed galanin receptors GalR2 and GalR3. Using chamber short-circuit current (Isc) measurements showed that application of galanin to human NCL-SG3 cells led to a significant increase in Isc, which was inhibited by the presence of chloride channel blockers and in chloride-free Krebs solution.

Original language	English
Pages (from-to)	141-143
Number of pages	3
Journal	Experimental Dermatology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1111/exd.12067
Publication status	Published - Feb 2013

Keywords

galanin
sweat glands
galanin receptor
chloride

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10.1111/exd.12067

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Bovell, D., Holub, B. S., Odusanwo, O., Brodowicz, B., Rauch, I., Kofler, B., & Lang, R. (2013). Galanin is a modulator of eccrine sweat gland secretion. Experimental Dermatology, 22(2), 141-143. https://doi.org/10.1111/exd.12067

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abstract = "The neuropeptide galanin has been ascribed different roles in modulating physiological functions in the skin. The present study examined the function of galanin in eccrine sweat gland physiology. We demonstrated secretion of galanin by sweat glands in vivo by radioimmunoassay of human sweat (20-192 fmol galanin/ml). Furthermore, human sweat glands expressed galanin receptors GalR2 and GalR3. Using chamber short-circuit current (Isc) measurements showed that application of galanin to human NCL-SG3 cells led to a significant increase in Isc, which was inhibited by the presence of chloride channel blockers and in chloride-free Krebs solution.",

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AU - Bovell, Douglas

AU - Holub, Barbara S.

AU - Odusanwo, Olutayo

AU - Brodowicz, Bernhard

AU - Rauch, Isabella

AU - Kofler, Barbara

AU - Lang, Roland

PY - 2013/2

Y1 - 2013/2

N2 - The neuropeptide galanin has been ascribed different roles in modulating physiological functions in the skin. The present study examined the function of galanin in eccrine sweat gland physiology. We demonstrated secretion of galanin by sweat glands in vivo by radioimmunoassay of human sweat (20-192 fmol galanin/ml). Furthermore, human sweat glands expressed galanin receptors GalR2 and GalR3. Using chamber short-circuit current (Isc) measurements showed that application of galanin to human NCL-SG3 cells led to a significant increase in Isc, which was inhibited by the presence of chloride channel blockers and in chloride-free Krebs solution.

AB - The neuropeptide galanin has been ascribed different roles in modulating physiological functions in the skin. The present study examined the function of galanin in eccrine sweat gland physiology. We demonstrated secretion of galanin by sweat glands in vivo by radioimmunoassay of human sweat (20-192 fmol galanin/ml). Furthermore, human sweat glands expressed galanin receptors GalR2 and GalR3. Using chamber short-circuit current (Isc) measurements showed that application of galanin to human NCL-SG3 cells led to a significant increase in Isc, which was inhibited by the presence of chloride channel blockers and in chloride-free Krebs solution.

KW - galanin

KW - sweat glands

KW - galanin receptor

KW - chloride

U2 - 10.1111/exd.12067

DO - 10.1111/exd.12067

M3 - Article

VL - 22

SP - 141

EP - 143

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 0906-6705

IS - 2

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