TY - JOUR
T1 - Fungi at the scene of the crime: innocent bystanders or accomplices in oral infections?
AU - Delaney, Christopher
AU - Kean, Ryan
AU - Short, Bryn
AU - Tumelty, Maria
AU - McLean, William
AU - Nile, Christopher
AU - Ramage, Gordon
N1 - Acceptance date tbc; req'd 20/11/18 DC
PY - 2018/9/30
Y1 - 2018/9/30
N2 - Purpose of Review: Over the last decade, microbiome studies have enhanced our knowledge and understanding of the polymicrobial nature of oral infections. Recently, profiling of the fungal microbiome has expanded our conventional understanding of oral ecology, revealing the critical importance of yeasts within this complex microbiome. This review aims to explore our current appreciation of interkingdom interactions in oral disease. Recent Findings: There is a growing evidence base of interactions and pathogenic synergy and antagonism with bacterial species within oral disease. Recent studies have helped to develop our knowledge of how Candida albicans, alongside bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Lactobacillus species, influence overall pathogenicity. Summary: Clinical and experimental evidence makes a compelling case for a role for C. albicans in a number of oral infections, though whether its role is an active accomplice or passive bystander remains to be determined.
AB - Purpose of Review: Over the last decade, microbiome studies have enhanced our knowledge and understanding of the polymicrobial nature of oral infections. Recently, profiling of the fungal microbiome has expanded our conventional understanding of oral ecology, revealing the critical importance of yeasts within this complex microbiome. This review aims to explore our current appreciation of interkingdom interactions in oral disease. Recent Findings: There is a growing evidence base of interactions and pathogenic synergy and antagonism with bacterial species within oral disease. Recent studies have helped to develop our knowledge of how Candida albicans, alongside bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Lactobacillus species, influence overall pathogenicity. Summary: Clinical and experimental evidence makes a compelling case for a role for C. albicans in a number of oral infections, though whether its role is an active accomplice or passive bystander remains to be determined.
KW - fungi
KW - oral infections
KW - mycology
U2 - 10.1007/s40588-018-0100-3
DO - 10.1007/s40588-018-0100-3
M3 - Article
VL - 5
SP - 190
EP - 200
JO - Current Clinical Microbiology Reports
JF - Current Clinical Microbiology Reports
SN - 2196-5471
IS - 3
ER -