Fungi at the scene of the crime: innocent bystanders or accomplices in oral infections?

Christopher Delaney, Ryan Kean, Bryn Short, Maria Tumelty, William McLean, Christopher Nile, Gordon Ramage

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)
102 Downloads (Pure)


Purpose of Review: Over the last decade, microbiome studies have enhanced our knowledge and understanding of the polymicrobial nature of oral infections. Recently, profiling of the fungal microbiome has expanded our conventional understanding of oral ecology, revealing the critical importance of yeasts within this complex microbiome. This review aims to explore our current appreciation of interkingdom interactions in oral disease. Recent Findings: There is a growing evidence base of interactions and pathogenic synergy and antagonism with bacterial species within oral disease. Recent studies have helped to develop our knowledge of how Candida albicans, alongside bacteria such as Porphyromonas gingivalis, Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and Lactobacillus species, influence overall pathogenicity. Summary: Clinical and experimental evidence makes a compelling case for a role for C. albicans in a number of oral infections, though whether its role is an active accomplice or passive bystander remains to be determined.
Original languageEnglish
Pages (from-to)190-200
Number of pages11
JournalCurrent Clinical Microbiology Reports
Issue number3
Early online date30 Jun 2018
Publication statusPublished - 30 Sep 2018


  • biofilm
  • candida
  • interkingdom
  • oral cavity
  • polymicrobial

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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