Factors associated with spontaneous clearance of chronic hepatitis C virus infection

Naomi Bulteel, Prasanna Sarathy, Ewan Forrest, Adrian Stanley, Hamish Innes, Peter Mills, Heather Valerio, Rory Gunson, Celia Aitken, Judith Morris, Ray Fox, Stephen T Barclay

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Spontaneous clearance of chronic hepatitis C virus (HCV) infection (CHC) is rare. We conducted a retrospective case control study to identify rates and factors associated with spontaneous clearance of CHC. We defined a case as an individual who spontaneously resolved CHC, and a control as an individual that remained chronically infected. We used data obtained on HCV testing between 1994 and 2013 in the West of Scotland to infer case/control status. Specifically, untreated patients with = 2 sequential samples positive for HCV RNA = 6 months apart followed by = 1 negative test, and those with = 2 positive samples = 6 months apart with no subsequent negative samples were identified. Control patients were randomly selected from the second group (4/patient of interest). Case notes were reviewed and patient characteristics obtained.
Original languageEnglish
Pages (from-to)266–272
Number of pages7
JournalJournal of Hepatology
Issue number2
Early online date4 May 2016
Publication statusPublished - Aug 2016



  • hepatitis C virus
  • chronic illness
  • virology

Cite this

Bulteel, N., Sarathy, P., Forrest, E., Stanley, A., Innes, H., Mills, P., Valerio, H., Gunson, R., Aitken, C., Morris, J., Fox, R., & Barclay , S. T. (2016). Factors associated with spontaneous clearance of chronic hepatitis C virus infection. Journal of Hepatology, 65(2), 266–272. https://doi.org/10.1016/j.jhep.2016.04.030