Expression of recipient cytomegalovirus in immunosuppressed and xenotransplanted Macaca fascicularis may be related to more severe gastrointestinal lesions

Laura Cavicchioli, Rossella Zanetti, Serena Ferraresso, Claire Crossan, Peter A. Barry, Massimo Boldrin, Marta Vadori, Silvia Ferro, Fiorella Calabrese, Linda Scobie, Emanuele Cozzi, Valentina Zappulli

Research output: Contribution to journalArticle

Abstract

Xenotransplantation is a potential answer to the current organ shortage, but the risk of infections related to overimmunosuppression is an important parameter that may predict the recipient's long-term survival. Cytomegalovirus (CMV) in xenotransplanted and immunosuppressed primates is a well-known cause of disease particularly affecting the gastrointestinal (GI) tract and a zoonotic concern
Original languageEnglish
Pages (from-to)135–143
Number of pages9
JournalXenotransplantation
Volume22
Issue number2
Early online date12 Feb 2015
DOIs
Publication statusPublished - Mar 2015

Keywords

  • cytomegalovirus
  • infections
  • immunosuppression

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