Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety

Ashley Taylor, Nigel Irwin, Aine McKillop, Steven Patterson, Peter Flatt, Victor Gault

Research output: Contribution to journalArticle

Abstract

Recently, glucagon-like peptide 1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP) have received much attention regarding possible roles in aetiology and treatment of type 2 diabetes. However, peptides co-secreted from the same enteroendocrine cells are less well studied. The present investigation was designed to characterise the in vitro and in vivo effects of xenin, a peptide co-secreted with GIP from intestinal K-cells. We examined the enzymatic stability, insulin-releasing activity and associated cAMP production capability of xenin in vitro. In addition, the effects of xenin on satiety, glucose homoeostasis and insulin secretion were examined in vivo.
Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalJournal of Endocrinology
Volume207
Issue number1
DOIs
Publication statusPublished - Oct 2010

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Keywords

  • xenin peptide
  • insulin secretion
  • type 2 diabetes
  • glucose homoeostasis

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