Evaluation of equine laminar veins: harvesting; dissection and the use of functional method to distinguish between veins and arteries

Chris Hillier, John A. Keen, Bruce C. McGorum, David Bunton, Jane E. Nally

Research output: Contribution to journalArticle

Abstract

Pharmacological evaluation of the unique equine laminar microvasculature is crucial to understanding its role in health and in diseases such as laminitis. However, separating the distinctive characteristics of arterial versus venous components of this complex vascular network has previously proved to be extremely difficult. Encased in a hard hoof capsule, isolation of individual blood vessels presents a considerable challenge. Exacerbating this difficulty, the laminar venous network is adapted to sustain high intravascular pressures and consequently has thickened walls, making the normally straightforward visual distinction between arteries and veins problematic. Here we describe a novel harvesting and dissection method coupled with a functional analysis procedure that facilitates distinction of arteries and veins.

Original languageEnglish
Pages (from-to)92-99
Number of pages8
JournalJournal of Pharmacological and Toxicological Methods
Volume57
Issue number2
DOIs
Publication statusPublished - 1 Apr 2008

Keywords

  • laminar veins
  • equine
  • laminitis
  • endothelin 1

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