Estimating the number of people with hepatitis C virus who have ever injected drugs and have yet to be diagnosed: an evidence synthesis approach for Scotland

Teresa C. Prevost, Anne M. Presanis, Avril Taylor, David Goldberg, Sharon J. Hutchinson, Daniela De Angelis

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Abstract

Aims

To estimate the number of people who have ever injected drugs (defined here as PWID) living in Scotland in 2009 who have been infected with the hepatitis C virus (HCV) and to quantify and characterize the population remaining undiagnosed.
Methods

Information from routine surveillance (n¿=¿22¿616) and survey data (n¿=¿2511) was combined using a multiparameter evidence synthesis approach to estimate the size of the PWID population, HCV antibody prevalence and the proportion of HCV antibody prevalent cases who have been diagnosed, in subgroups defined by recency of injecting (in the last year or not), age (15–34 and 35–64¿years), gender and region of residence (Greater Glasgow and Clyde and the rest of Scotland).
Results

HCV antibody-prevalence among PWID in Scotland during 2009 was estimated to be 57% [95% CI=52-61%], corresponding to 46¿657 [95% credible interval (CI)¿=¿33¿812–66¿803] prevalent cases. Of these, 27¿434 (95% CI¿=¿14¿636–47¿564) were undiagnosed, representing 59% [95% CI=43-71%] of prevalent cases. Among the undiagnosed, 83% (95% CI¿=¿75–89%) were PWID who had not injected in the last year and 71% (95% CI¿=¿58–85%) were aged 35–64 years.
Conclusions

The number of undiagnosed hepatitis C virus-infected cases in Scotland appears to be particularly high among those who have injected drugs more than 1¿year ago and are more than 35¿years old.
Original languageEnglish
Pages (from-to)1287-300
Number of pages14
JournalAddiction
Volume110
Issue number8
Early online date8 Jun 2015
DOIs
Publication statusPublished - Aug 2015

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Scotland
Hepacivirus
Hepatitis C Antibodies
Pharmaceutical Preparations
Population Density
Antibodies
Population

Keywords

  • hepatitis C
  • evidence synthesis
  • people who inject drugs
  • prevalence

Cite this

@article{bfe65eb292cd4465ad084c3a32ceeb39,
title = "Estimating the number of people with hepatitis C virus who have ever injected drugs and have yet to be diagnosed: an evidence synthesis approach for Scotland",
abstract = "AimsTo estimate the number of people who have ever injected drugs (defined here as PWID) living in Scotland in 2009 who have been infected with the hepatitis C virus (HCV) and to quantify and characterize the population remaining undiagnosed.MethodsInformation from routine surveillance (n¿=¿22¿616) and survey data (n¿=¿2511) was combined using a multiparameter evidence synthesis approach to estimate the size of the PWID population, HCV antibody prevalence and the proportion of HCV antibody prevalent cases who have been diagnosed, in subgroups defined by recency of injecting (in the last year or not), age (15–34 and 35–64¿years), gender and region of residence (Greater Glasgow and Clyde and the rest of Scotland).ResultsHCV antibody-prevalence among PWID in Scotland during 2009 was estimated to be 57{\%} [95{\%} CI=52-61{\%}], corresponding to 46¿657 [95{\%} credible interval (CI)¿=¿33¿812–66¿803] prevalent cases. Of these, 27¿434 (95{\%} CI¿=¿14¿636–47¿564) were undiagnosed, representing 59{\%} [95{\%} CI=43-71{\%}] of prevalent cases. Among the undiagnosed, 83{\%} (95{\%} CI¿=¿75–89{\%}) were PWID who had not injected in the last year and 71{\%} (95{\%} CI¿=¿58–85{\%}) were aged 35–64 years.ConclusionsThe number of undiagnosed hepatitis C virus-infected cases in Scotland appears to be particularly high among those who have injected drugs more than 1¿year ago and are more than 35¿years old.",
keywords = "hepatitis C, evidence synthesis, people who inject drugs, prevalence",
author = "Prevost, {Teresa C.} and Presanis, {Anne M.} and Avril Taylor and David Goldberg and Hutchinson, {Sharon J.} and {De Angelis}, Daniela",
year = "2015",
month = "8",
doi = "10.1111/add.12948",
language = "English",
volume = "110",
pages = "1287--300",
journal = "Addiction",
issn = "0965-2140",
number = "8",

}

Estimating the number of people with hepatitis C virus who have ever injected drugs and have yet to be diagnosed : an evidence synthesis approach for Scotland. / Prevost, Teresa C.; Presanis, Anne M.; Taylor, Avril; Goldberg, David; Hutchinson, Sharon J.; De Angelis, Daniela.

In: Addiction, Vol. 110, No. 8, 08.2015, p. 1287-300.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Estimating the number of people with hepatitis C virus who have ever injected drugs and have yet to be diagnosed

T2 - an evidence synthesis approach for Scotland

AU - Prevost, Teresa C.

AU - Presanis, Anne M.

AU - Taylor, Avril

AU - Goldberg, David

AU - Hutchinson, Sharon J.

AU - De Angelis, Daniela

PY - 2015/8

Y1 - 2015/8

N2 - AimsTo estimate the number of people who have ever injected drugs (defined here as PWID) living in Scotland in 2009 who have been infected with the hepatitis C virus (HCV) and to quantify and characterize the population remaining undiagnosed.MethodsInformation from routine surveillance (n¿=¿22¿616) and survey data (n¿=¿2511) was combined using a multiparameter evidence synthesis approach to estimate the size of the PWID population, HCV antibody prevalence and the proportion of HCV antibody prevalent cases who have been diagnosed, in subgroups defined by recency of injecting (in the last year or not), age (15–34 and 35–64¿years), gender and region of residence (Greater Glasgow and Clyde and the rest of Scotland).ResultsHCV antibody-prevalence among PWID in Scotland during 2009 was estimated to be 57% [95% CI=52-61%], corresponding to 46¿657 [95% credible interval (CI)¿=¿33¿812–66¿803] prevalent cases. Of these, 27¿434 (95% CI¿=¿14¿636–47¿564) were undiagnosed, representing 59% [95% CI=43-71%] of prevalent cases. Among the undiagnosed, 83% (95% CI¿=¿75–89%) were PWID who had not injected in the last year and 71% (95% CI¿=¿58–85%) were aged 35–64 years.ConclusionsThe number of undiagnosed hepatitis C virus-infected cases in Scotland appears to be particularly high among those who have injected drugs more than 1¿year ago and are more than 35¿years old.

AB - AimsTo estimate the number of people who have ever injected drugs (defined here as PWID) living in Scotland in 2009 who have been infected with the hepatitis C virus (HCV) and to quantify and characterize the population remaining undiagnosed.MethodsInformation from routine surveillance (n¿=¿22¿616) and survey data (n¿=¿2511) was combined using a multiparameter evidence synthesis approach to estimate the size of the PWID population, HCV antibody prevalence and the proportion of HCV antibody prevalent cases who have been diagnosed, in subgroups defined by recency of injecting (in the last year or not), age (15–34 and 35–64¿years), gender and region of residence (Greater Glasgow and Clyde and the rest of Scotland).ResultsHCV antibody-prevalence among PWID in Scotland during 2009 was estimated to be 57% [95% CI=52-61%], corresponding to 46¿657 [95% credible interval (CI)¿=¿33¿812–66¿803] prevalent cases. Of these, 27¿434 (95% CI¿=¿14¿636–47¿564) were undiagnosed, representing 59% [95% CI=43-71%] of prevalent cases. Among the undiagnosed, 83% (95% CI¿=¿75–89%) were PWID who had not injected in the last year and 71% (95% CI¿=¿58–85%) were aged 35–64 years.ConclusionsThe number of undiagnosed hepatitis C virus-infected cases in Scotland appears to be particularly high among those who have injected drugs more than 1¿year ago and are more than 35¿years old.

KW - hepatitis C

KW - evidence synthesis

KW - people who inject drugs

KW - prevalence

U2 - 10.1111/add.12948

DO - 10.1111/add.12948

M3 - Article

VL - 110

SP - 1287

EP - 1300

JO - Addiction

JF - Addiction

SN - 0965-2140

IS - 8

ER -