Endothelium-derived hyperpolarizing factor: identification and mechanisms of action in human subcutaneous resistance arteries

Paul Coats, Fiona Johnston, John MacDonald, John J.V. McMurray, Chris Hillier

Research output: Contribution to journalArticle


Both a vascular endothelial cytochrome P450 (CYP450) product of arachidonic acid metabolism and the potassium ion (K+) have been identified as endothelium-derived hyperpolarizing factors (EDHFs) in animal vascular tissues. We studied the relative importance of EDHF, nitric oxide (NO), and prostacyclin (PGI2) as vasodilators in human subcutaneous arteries. We also examined the mechanisms underlying the vasodilator action of EDHF to elucidate its identity.

Original languageEnglish
Pages (from-to)1702-1708
Number of pages7
Issue number12
Publication statusPublished - 1 Mar 2001



  • human subcutaneous resistance arteries
  • vascular disease
  • endothelium-derived hyperpolarizing factor

Cite this