Endothelium-derived hyperpolarizing factor: identification and mechanisms of action in human subcutaneous resistance arteries

Paul Coats; Fiona Johnston; John MacDonald; John J.V. McMurray; Chris Hillier

Endothelium-derived hyperpolarizing factor: identification and mechanisms of action in human subcutaneous resistance arteries

Paul Coats, Fiona Johnston, John MacDonald, John J.V. McMurray, Chris Hillier

Biological and Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

Both a vascular endothelial cytochrome P450 (CYP450) product of arachidonic acid metabolism and the potassium ion (K+) have been identified as endothelium-derived hyperpolarizing factors (EDHFs) in animal vascular tissues. We studied the relative importance of EDHF, nitric oxide (NO), and prostacyclin (PGI2) as vasodilators in human subcutaneous arteries. We also examined the mechanisms underlying the vasodilator action of EDHF to elucidate its identity.

Original language	English
Pages (from-to)	1702-1708
Number of pages	7
Journal	Circulation
Volume	103
Issue number	12
Publication status	Published - 1 Mar 2001

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Keywords

human subcutaneous resistance arteries
vascular disease
endothelium-derived hyperpolarizing factor

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Coats, P., Johnston, F., MacDonald, J., McMurray, J. J. V., & Hillier, C. (2001). Endothelium-derived hyperpolarizing factor: identification and mechanisms of action in human subcutaneous resistance arteries. Circulation, 103(12), 1702-1708. http://researchonline.gcu.ac.uk/sls/60

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title = "Endothelium-derived hyperpolarizing factor: identification and mechanisms of action in human subcutaneous resistance arteries",

abstract = "Both a vascular endothelial cytochrome P450 (CYP450) product of arachidonic acid metabolism and the potassium ion (K+) have been identified as endothelium-derived hyperpolarizing factors (EDHFs) in animal vascular tissues. We studied the relative importance of EDHF, nitric oxide (NO), and prostacyclin (PGI2) as vasodilators in human subcutaneous arteries. We also examined the mechanisms underlying the vasodilator action of EDHF to elucidate its identity.",

keywords = "human subcutaneous resistance arteries, vascular disease, endothelium-derived hyperpolarizing factor",

author = "Paul Coats and Fiona Johnston and John MacDonald and McMurray, {John J.V.} and Chris Hillier",

note = "<p>Originally published in: Circulation (2001), 103 (12), pp.1702-1708.</p>",

year = "2001",

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language = "English",

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journal = "Circulation",

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TY - JOUR

T1 - Endothelium-derived hyperpolarizing factor: identification and mechanisms of action in human subcutaneous resistance arteries

AU - Coats, Paul

AU - Johnston, Fiona

AU - MacDonald, John

AU - McMurray, John J.V.

AU - Hillier, Chris

N1 - <p>Originally published in: Circulation (2001), 103 (12), pp.1702-1708.</p>

PY - 2001/3/1

Y1 - 2001/3/1

N2 - Both a vascular endothelial cytochrome P450 (CYP450) product of arachidonic acid metabolism and the potassium ion (K+) have been identified as endothelium-derived hyperpolarizing factors (EDHFs) in animal vascular tissues. We studied the relative importance of EDHF, nitric oxide (NO), and prostacyclin (PGI2) as vasodilators in human subcutaneous arteries. We also examined the mechanisms underlying the vasodilator action of EDHF to elucidate its identity.

AB - Both a vascular endothelial cytochrome P450 (CYP450) product of arachidonic acid metabolism and the potassium ion (K+) have been identified as endothelium-derived hyperpolarizing factors (EDHFs) in animal vascular tissues. We studied the relative importance of EDHF, nitric oxide (NO), and prostacyclin (PGI2) as vasodilators in human subcutaneous arteries. We also examined the mechanisms underlying the vasodilator action of EDHF to elucidate its identity.

KW - human subcutaneous resistance arteries

KW - vascular disease

KW - endothelium-derived hyperpolarizing factor

M3 - Article

VL - 103

SP - 1702

EP - 1708

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 12

ER -

Endothelium-derived hyperpolarizing factor: identification and mechanisms of action in human subcutaneous resistance arteries

Abstract

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Keywords

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