Endothelin mediated contraction of equine laminar veins

John A. Keen, Bruce C. McGorum, Chris Hillier, Jane E. Nally

Research output: Contribution to journalArticle

Abstract

Endothelin-1 (ET-1) may be a key mediator in the pathogenesis of laminitis, but endothelin-mediated responses in the venous microcirculation of the equine foot have yet to be fully characterised. The aim of this study was to characterise the response of equine laminar veins to ET-1 and evaluate the ET-1 receptor subtypes that mediate this response. Small veins (150–500 µm) draining the equine digital laminae from healthy horses and ponies subjected to euthanasia at an abattoir were investigated using wire myography. Concentration response curves were constructed for ET-1 in the presence of ETA (BQ123) and ETB (BQ788) receptor antagonists, and L-NAME, a nitric oxide synthase blocker. The selective ETB receptor agonist BQ3020 was investigated alone and following incubation with L-NAME, with or without BQ788.

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalEquine Veterinary Journal
Volume40
Issue number5
DOIs
Publication statusPublished - 1 Jul 2008

Keywords

  • equine biology
  • laminar veins
  • vascular
  • laminitis
  • endothelin-1

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