Effects of physical activity changes induced by behaviour change interventions on inflammation and patient-centred outcomes in breast cancer survivors: a systematic review

Elochukwu Fortune Ezenwankwo*, Antoninus Obinna Ezeukwu, Ukachukwu Okoroafor Abaraogu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
9 Downloads (Pure)

Abstract

Purpose
Ample evidence supports using behaviour change interventions to increase physical activity (PA) in breast cancer survivors (BCSs). This systematic review aims to investigate if behaviour change intervention-induced changes in PA can modulate inflammation and improve patient-centred outcomes in this population.

Methods
We searched six databases and synthesised evidence from 17 RCTs reporting between-group changes for inflammatory biomarkers, cancer-related fatigue (CRF), aerobic fitness, and/or quality of life (QoL).

Results
Two RCTs reported small-to-medium effect size decreases in the ratios of IL-6:IL-10 and TNF-a:IL-10 at 12 weeks. Five RCTs reported significant intervention improvements in aerobic fitness; three trials further showed sustained intervention effects at two- and three-month follow-up. Four trials reported beneficial reductions in CRF post-intervention and three trials showed sustained intervention effects at follow-up. Three trials showed significant improvements in QoL at three and six months, with two trials demonstrating sustained intervention effects at two- and three-month follow-up. Further, six trials reported significant improvements in at least one QoL variable.

Conclusion
We found limited but plausible evidence to support the beneficial effects of PA behaviour change interventions on inflammation and patient-centred outcomes in BCSs. Larger RCTs are particularly warranted to explore the causal impact on cytokine balance and possible mediating effects on patient-centred outcomes.
Original languageEnglish
JournalEuropean Journal of Physiotherapy
Early online date10 Jun 2021
DOIs
Publication statusE-pub ahead of print - 10 Jun 2021

Keywords

  • breast cancer survivors
  • behavior change interventions
  • physical activity
  • inflammation
  • patient-centred outcomes

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation

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