Effects of glaucoma and snoring on cerebral oxygenation in the visual cortex: a study using functional Near Infrared Spectroscopy (fNIRS)

Laura M. Ward, Ross T. Aitchison, Gemma Hill, Jayne Imrie, Anita J. Simmers, Gordon Morrison, David Mansfield, Graeme J. Kennedy, Uma Shahani*

*Corresponding author for this work

Research output: Contribution to journalArticle

91 Downloads (Pure)

Abstract

Purpose: The purpose of this study was to investigate the effects of snoring and glaucoma on the visual Haemodynamic Response(HDR) using functional Near Infrared Spectroscopy (fNIRS).
Methods: We recruited 8 glaucoma patients (aged 56-79), 6 habitual snorers (aged 26-61) and 10 healthy control participants (aged 21-78). Glaucoma patients were of varying subtypes and under care of ophthalmologists. Prior to testing visual acuity, blood pressure,heart rate and a medical history were taken. HDRs were recorded over the primary visual cortex (V1) using a reversing checkerboard paradigm.
Results & Discussion: All participants showed the characteristic increase of Oxyhaemoglobin concentration ([HbO]) and decrease of Deoxyhaemoglobin concentration ([HbR]) during visual stimulation (p < 0.001, ¿2 = 0.78). Despite this, there were signifi cant group differences with a large effect size (¿2 = 0.28). During visual stimulation normal participants had greater [HbO] compared to snorers and glaucoma patients (p < 0.01). Both glaucoma patients and snorers presented with comparable HDR for [HbO] and [HbR] in V1. Importantly, during visual stimulation, the increased [HbO] in glaucoma patients correlated well with their visual fields and self-reported activities of daily living (r = -0.98, r = -0.82, p < 0.05). Both glaucoma patients and snorers presented with an attenuated HDR in V1. Our results suggest a possible vascular link between these conditions.
Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalInternational Journal of Ophthalmology and Vision Research
Volume2
Issue number2
Publication statusPublished - 26 Oct 2018

Keywords

  • glaucoma
  • haemodynamic response
  • oxyhaemoglobin
  • deoxyhaemoglobin
  • snorers
  • visual cortex
  • fNIRS

Fingerprint Dive into the research topics of 'Effects of glaucoma and snoring on cerebral oxygenation in the visual cortex: a study using functional Near Infrared Spectroscopy (fNIRS)'. Together they form a unique fingerprint.

  • Profiles

    Cite this