Effects of felodipine on atrial natriuretic peptide in hypertensive non‐ insulin dependent diabetes mellitus.

RF Jeffrey; S. Capewell; J. Brown; A. Collier; C. Hajducka; MR Lee

doi:10.1111/j.1365-2125.1990.tb03801.x

Effects of felodipine on atrial natriuretic peptide in hypertensive non‐ insulin dependent diabetes mellitus.

RF Jeffrey^*, S. Capewell, J. Brown, A. Collier, C. Hajducka, MR Lee

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Eighteen patients with non‐insulin dependent diabetes mellitus and hypertension were treated during two 4 week periods with the calcium antagonist felodipine or placebo in a double‐blind, randomised, cross‐ over study. Mean systemic blood pressure was significantly lower on felodipine, without producing a deleterious effect on diabetic control. Felodipine was associated with an increment in plasma renin concentration but plasma aldosterone and the renal outputs of sodium and dopamine were similar on both treatments. Plasma atrial natriuretic peptide levels were significantly reduced following felodipine treatment.

Original language	English
Pages (from-to)	481-484
Number of pages	4
Journal	British Journal of Clinical Pharmacology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2125.1990.tb03801.x
Publication status	Published - Sept 1990
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Documents and Links

10.1111/j.1365-2125.1990.tb03801.x

Cite this

@article{de2efcf91ac44b84b8bdbe9e260ba480,

title = "Effects of felodipine on atrial natriuretic peptide in hypertensive non‐ insulin dependent diabetes mellitus.",

abstract = "Eighteen patients with non‐insulin dependent diabetes mellitus and hypertension were treated during two 4 week periods with the calcium antagonist felodipine or placebo in a double‐blind, randomised, cross‐ over study. Mean systemic blood pressure was significantly lower on felodipine, without producing a deleterious effect on diabetic control. Felodipine was associated with an increment in plasma renin concentration but plasma aldosterone and the renal outputs of sodium and dopamine were similar on both treatments. Plasma atrial natriuretic peptide levels were significantly reduced following felodipine treatment.",

author = "RF Jeffrey and S. Capewell and J. Brown and A. Collier and C. Hajducka and MR Lee",

year = "1990",

month = sep,

doi = "10.1111/j.1365-2125.1990.tb03801.x",

language = "English",

volume = "30",

pages = "481--484",

journal = "British Journal of Clinical Pharmacology",

issn = "0306-5251",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "3",

}

TY - JOUR

T1 - Effects of felodipine on atrial natriuretic peptide in hypertensive non‐ insulin dependent diabetes mellitus.

AU - Jeffrey, RF

AU - Capewell, S.

AU - Brown, J.

AU - Collier, A.

AU - Hajducka, C.

AU - Lee, MR

PY - 1990/9

Y1 - 1990/9

N2 - Eighteen patients with non‐insulin dependent diabetes mellitus and hypertension were treated during two 4 week periods with the calcium antagonist felodipine or placebo in a double‐blind, randomised, cross‐ over study. Mean systemic blood pressure was significantly lower on felodipine, without producing a deleterious effect on diabetic control. Felodipine was associated with an increment in plasma renin concentration but plasma aldosterone and the renal outputs of sodium and dopamine were similar on both treatments. Plasma atrial natriuretic peptide levels were significantly reduced following felodipine treatment.

AB - Eighteen patients with non‐insulin dependent diabetes mellitus and hypertension were treated during two 4 week periods with the calcium antagonist felodipine or placebo in a double‐blind, randomised, cross‐ over study. Mean systemic blood pressure was significantly lower on felodipine, without producing a deleterious effect on diabetic control. Felodipine was associated with an increment in plasma renin concentration but plasma aldosterone and the renal outputs of sodium and dopamine were similar on both treatments. Plasma atrial natriuretic peptide levels were significantly reduced following felodipine treatment.

U2 - 10.1111/j.1365-2125.1990.tb03801.x

DO - 10.1111/j.1365-2125.1990.tb03801.x

M3 - Article

C2 - 2145957

AN - SCOPUS:0025082347

SN - 0306-5251

VL - 30

SP - 481

EP - 484

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 3

ER -

Effects of felodipine on atrial natriuretic peptide in hypertensive non‐ insulin dependent diabetes mellitus.

Abstract

ASJC Scopus subject areas

UN SDGs

Documents and Links

Fingerprint

Cite this