Effect of tear supplements on signs, symptoms and inflammatory markers in dry eye

Eilidh Martin*, Katherine M. Oliver, E. Ian Pearce, Alan Tomlinson, Peter Simmons, Suzanne Hagan

*Corresponding author for this work

Research output: Contribution to journalArticle

101 Downloads (Pure)

Abstract

Purpose

Three tear supplements were compared for their effects on the signs, symptoms and inflammatory status of subjects with dry eye disease. Assessments were made before and after both 2 and 4¿weeks of treatment.

Methods

In this masked, randomized, 3-way crossover trial, eighteen dry eye subjects were recruited. At each visit, symptoms, tear evaporation rate, stability and osmolarity were measured and tear samples were analyzed for 7 inflammatory markers, using multiplex immunoassays. The 3 treatments included carboxymethylcellulose-glycerine-castor oil (CGC), carboxymethylcellulose (CMC) and hydroxypropyl guar (HPG). The CGC and HPG drops are emulsified lipids; CGC also contains osmoprotectants. The CMC drop is a standard aqueous polymeric supplement.

Results

Significant improvements were seen in symptoms (OSDI) and tear stability (NITBUT) with all 3 treatments at 4¿weeks. At 4¿weeks post-CGC, 6 out of 7 biomarkers demonstrated a >25% reduction (in 40% of subjects). The same reduction (>25%) was seen in 10% of the subjects for CMC and in none of the subjects for HPG. No significantly different change to either evaporation rate or tear osmolarity was found following any of the three treatments.

Conclusions

In this study, the CGC treatment resulted in the greatest reduction in ocular biomarkers of inflammation, while all 3 treatments reduced symptoms and improved tear stability. These results indicate that subject-perceived symptomatic improvements are not necessarily associated with a reduction in objective measures of inflammation.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalCytokine
Volume105
Early online date14 Feb 2018
DOIs
Publication statusPublished - May 2018

Keywords

  • dry eye disease
  • cytokines
  • biomarkers
  • tears
  • inflammation

Fingerprint Dive into the research topics of 'Effect of tear supplements on signs, symptoms and inflammatory markers in dry eye'. Together they form a unique fingerprint.

  • Cite this