Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10¿801 women in 17 randomised trials

Research output: Contribution to journalArticle

Abstract

After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.
Original languageEnglish
Pages (from-to)1707-1716
Number of pages10
JournalLancet
Volume378
Issue number9804
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Radiotherapy
Surgery
Meta-analysis
Breast Cancer

Keywords

  • radiotherapy
  • breast cancer
  • surgery

Cite this

@article{a176db7a923f4841aeb778697acaedee,
title = "Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10¿801 women in 17 randomised trials",
abstract = "After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.",
keywords = "radiotherapy, breast cancer, surgery",
author = "S. Darby and P. McGale and C. Correa and C. Taylor and R. Arriagada and M. Clarke and D. Cutter and C. Davies and M. Ewertz and J. Godwin and R. Gray and L. Pierce and T. Whelan and Y. Wang and R. Peto",
year = "2011",
month = "11",
doi = "10.1016/S0140-6736(11)61629-2",
language = "English",
volume = "378",
pages = "1707--1716",
journal = "Lancet",
issn = "0140-6736",
publisher = "Elsevier Ltd",
number = "9804",

}

TY - JOUR

T1 - Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10¿801 women in 17 randomised trials

AU - Darby, S.

AU - McGale, P.

AU - Correa, C.

AU - Taylor, C.

AU - Arriagada, R.

AU - Clarke, M.

AU - Cutter, D.

AU - Davies, C.

AU - Ewertz, M.

AU - Godwin, J.

AU - Gray, R.

AU - Pierce, L.

AU - Whelan, T.

AU - Wang, Y.

AU - Peto, R.

PY - 2011/11

Y1 - 2011/11

N2 - After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.

AB - After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.

KW - radiotherapy

KW - breast cancer

KW - surgery

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-81055155920&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(11)61629-2

DO - 10.1016/S0140-6736(11)61629-2

M3 - Article

AN - SCOPUS:81055155920

VL - 378

SP - 1707

EP - 1716

JO - Lancet

JF - Lancet

SN - 0140-6736

IS - 9804

ER -