Effect of diet-induced obesity on protein expression in insulin signalling pathways of skeletal muscle in male Wistar rats

Sameer Fatani, Abdul-Razak Abubakari, Imose Itua, Christopher Wong, Cecil Thomas, Ebrahim K. Naderali

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Abstract

The prevalence of diet-induced obesity is increasing globally, and posing significant health problems for millions of people worldwide. Diet-induced obesity is a major contributor to the global pandemic of type 2 diabetes mellitus. The reduced ability of muscle tissue to regulate glucose homeostasis plays a major role in the development and prognosis of type 2 diabetes. In this study, an animal model of diet-induced obesity was used to elucidate changes in skeletal muscle insulin signaling in obesity-induced diabetes.
Original languageEnglish
Pages (from-to)573-582
Number of pages10
JournalInternational Journal of General Medicine
Volume5
DOIs
Publication statusPublished - 2012

Keywords

  • obesity
  • diet
  • type 2 diabetes
  • insulin signalling

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