Dynamics of cardiac intracellular Ca2+ handling - From experiments to virtual cells

H. Zhang*, D. Noble, M. Cannell, C. H. Orchard, M. Lancaster, S. A. Jones, M. R. Boyett, A. V. Holden, M. Saleet Jafri, E. A. Sobie, W. J. Lederer, S. S. Demir, A. Michailova, F. Delprincipe, M. Egger, E. Niggli, G. L. Smith, C. M. Loughrey, N. MacQuaide, J. DempsterA. W. Trafford

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Intracellular cardiac Ca2+ handling involves interactions of numerous distinct cellular and macromolecular structures. Such interactions coordinate the complicated behaviors of individual processes into spatial and temporal coherent patterns of Ca2+ sparks, oscillations and traveling waves. Understanding the dynamical behaviors and functional roles of intracellular Ca2+ handling requires not only detailed experimental information about subcellular structures and dynamics, but also useful tools to integrate and analyze this information. This requires interactions between experimental and simulation results within a virtual cell.

Original languageEnglish
Pages (from-to)3535-3560
Number of pages26
JournalInternational Journal of Bifurcation and Chaos in Applied Sciences and Engineering
Issue number12
Publication statusPublished - Dec 2003


  • calcium spark
  • oscillation
  • Wave

ASJC Scopus subject areas

  • Modelling and Simulation
  • Engineering (miscellaneous)
  • General
  • Applied Mathematics


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