Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline

Paola Caruso, Margaret R MacLean, Raya Khanin, John McClure, Elaine Soon, Mark Southgate, Robert A MacDonald, Jenny A Greig, Keith E Robertson, Rachel Masson, Laura Denby, Yvonne Dempsie, Lu Long, Nicholas W Morrell, Andrew H Baker

Research output: Contribution to journalLiterature review

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that have the capacity to control protein production through binding "seed" sequences within a target mRNA. Each miRNA is capable of potentially controlling hundreds of genes. The regulation of miRNAs in the lung during the development of pulmonary arterial hypertension (PAH) is unknown. We screened lung miRNA profiles in a longitudinal and crossover design during the development of PAH caused by chronic hypoxia or monocrotaline in rats. We identified reduced expression of Dicer, involved in miRNA processing, during the onset of PAH after hypoxia. MiR-22, miR-30, and let-7f were downregulated, whereas miR-322 and miR-451 were upregulated significantly during the development of PAH in both models.
Original languageEnglish
Pages (from-to)716-723
Number of pages8
JournalArteriosclerosis, Thrombosis and Vascular Biology
Volume30
Issue number4
Early online date28 Jan 2010
DOIs
Publication statusPublished - 2010

Keywords

  • pulmonary hypertension
  • hypoxia
  • microRNAs

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    Caruso, P., MacLean, M. R., Khanin, R., McClure, J., Soon, E., Southgate, M., MacDonald, R. A., Greig, J. A., Robertson, K. E., Masson, R., Denby, L., Dempsie, Y., Long, L., Morrell, N. W., & Baker, A. H. (2010). Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis, Thrombosis and Vascular Biology, 30(4), 716-723. https://doi.org/10.1161/ATVBAHA.109.202028