Dose–response between frequency of interruption of sedentary time and fasting glucose, the dawn phenomenon and night-time glucose in Type 2 diabetes

A. C. Paing, K. A. McMillan, A. F. Kirk, A. Collier, A. Hewitt, S. F. M. Chastin

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Abstract

Aim: To explore the dose–response between frequency of interruption of sedentary time and basal glucose (fasting glucose, the dawn phenomenon and night-time glucose) in Type 2 diabetes. Methods: In a randomized three-treatment, two-period balanced incomplete block trial, 12 people with Type 2 diabetes (age, 60.0 ± 3.2 years; BMI, 30.2 ± 1.4 kg/m 2 ) completed two of three conditions: sitting for 7 h interrupted every 60 min (Condition 1), 30 min (Condition 2), and 15 min (Condition 3) by 3-min light-intensity walking breaks. The activPAL3 and FreeStyle Libre were used to assess physical activity/sedentary behaviour and continuous glucose profile. Standardized meals were provided, and changes in basal glucose of the nights and early mornings before and after treatment conditions were calculated (mean ± SE). Results: After treatment conditions, fasting glucose and duration of the dawn phenomenon were lower for Condition 3 (−1.0 ± 0.2 mmol/l, P 
Original languageEnglish
Pages (from-to)376-382
Number of pages7
JournalDiabetic Medicine
Volume36
Issue number3
Early online date12 Oct 2018
DOIs
Publication statusPublished - Mar 2019

Keywords

  • sedentary behavior
  • glucose
  • type 2 diabetes

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