Abstract
Design: Randomised three-treatment, two-period balanced incomplete block trial.
Methods: Twelve adults with type 2 diabetes (age, 60 ± 11 years; body mass index, 30.2 ± 4.7 kg/m2) participated in two of the following treatment conditions: sitting for 7 h interrupted by 3 min light-intensity walking breaks every (1) 60 min (Condition 1), (2) 30 min (Condition 2), and (3) 15 min (Condition 3). Postprandial glucose incremental area under the curves (iAUCs) and 21-h glucose total area under the curve (AUC) were measured using continuous glucose monitoring. Standardised meals were provided.
Results: Compared with Condition 1 (6.7 ± 0.8 mmol L-1·3.5 h-1), post-breakfast glucose iAUC was reduced for Condition 3 (3.5 ± 0.9 mmol L-1·3.5 h-1, p < 0.04). Post-lunch glucose iAUC was lower in Condition 3 (1.3 ± 0.9 mmol L-1·3.5 h-1, p < 0.03) and Condition 2 (2.1 ± 0.7 mmol L-1·3.5 h-1, p < 0.05) relative to Condition 1 (4.6 ± 0.8 mmol L-1·3.5 h-1). Condition 3 (1.0 ± 0.7 mmol L-1·3.5 h-1, p = 0.02) and Condition 2 (1.6 ± 0.6 mmol L-1·3.5 h-1, p < 0.04) attenuated post-dinner glucose iAUC compared with Condition 1 (4.0 ± 0.7 mmol L-1·3.5 h-1). Cumulative 10.5-h postprandial glucose iAUC was lower in Condition 3 than Condition 1 (p = 0.02). Condition 3 reduced 21-h glucose AUC compared with Condition 1 (p < 0.001) and Condition 2 (p = 0.002). However, post-breakfast glucose iAUC, cumulative 10.5-h postprandial glucose iAUC and 21-h glucose AUC were not different between Condition 2 and Condition 1 (p > 0.05).
Conclusions: There could be dose-response between frequency of breaks in sedentary time and glucose. Interrupting sedentary time every 15 min could produce better glucose control.
| Original language | English |
|---|---|
| Pages (from-to) | 808-813 |
| Number of pages | 6 |
| Journal | Journal of Science and Medicine in Sport |
| Volume | 22 |
| Issue number | 7 |
| Early online date | 31 Jan 2019 |
| DOIs | |
| Publication status | Published - Jul 2019 |
Fingerprint
Keywords
- diabetes mellitus
- glucose
- sedentary lifestyle
- exercise
Cite this
}
Dose-response between frequency of breaks in sedentary time and glucose control in type 2 diabetes: a proof of concept study. / Paing, Aye C.; McMillan, Kathryn A.; Kirk, Alison F.; Collier, Andrew; Hewitt, Allan; Chastin, Sebastien F.M.
In: Journal of Science and Medicine in Sport, Vol. 22, No. 7, 07.2019, p. 808-813.Research output: Contribution to journal › Article
TY - JOUR
T1 - Dose-response between frequency of breaks in sedentary time and glucose control in type 2 diabetes: a proof of concept study
AU - Paing, Aye C.
AU - McMillan, Kathryn A.
AU - Kirk, Alison F.
AU - Collier, Andrew
AU - Hewitt, Allan
AU - Chastin, Sebastien F.M.
N1 - Acceptance in SAN AAM version queried. 28/01/19 DC. Set the file to closed visibility - author confirmed will change manuscript 28/1/19 ET ^AAM rec'd 13/3/19; 12m embargo
PY - 2019/7
Y1 - 2019/7
N2 - Objectives: This study aimed to investigate dose-response between frequency of breaks in sedentary time and glucose control. Design: Randomised three-treatment, two-period balanced incomplete block trial.Methods: Twelve adults with type 2 diabetes (age, 60 ± 11 years; body mass index, 30.2 ± 4.7 kg/m2) participated in two of the following treatment conditions: sitting for 7 h interrupted by 3 min light-intensity walking breaks every (1) 60 min (Condition 1), (2) 30 min (Condition 2), and (3) 15 min (Condition 3). Postprandial glucose incremental area under the curves (iAUCs) and 21-h glucose total area under the curve (AUC) were measured using continuous glucose monitoring. Standardised meals were provided.Results: Compared with Condition 1 (6.7 ± 0.8 mmol L-1·3.5 h-1), post-breakfast glucose iAUC was reduced for Condition 3 (3.5 ± 0.9 mmol L-1·3.5 h-1, p < 0.04). Post-lunch glucose iAUC was lower in Condition 3 (1.3 ± 0.9 mmol L-1·3.5 h-1, p < 0.03) and Condition 2 (2.1 ± 0.7 mmol L-1·3.5 h-1, p < 0.05) relative to Condition 1 (4.6 ± 0.8 mmol L-1·3.5 h-1). Condition 3 (1.0 ± 0.7 mmol L-1·3.5 h-1, p = 0.02) and Condition 2 (1.6 ± 0.6 mmol L-1·3.5 h-1, p < 0.04) attenuated post-dinner glucose iAUC compared with Condition 1 (4.0 ± 0.7 mmol L-1·3.5 h-1). Cumulative 10.5-h postprandial glucose iAUC was lower in Condition 3 than Condition 1 (p = 0.02). Condition 3 reduced 21-h glucose AUC compared with Condition 1 (p < 0.001) and Condition 2 (p = 0.002). However, post-breakfast glucose iAUC, cumulative 10.5-h postprandial glucose iAUC and 21-h glucose AUC were not different between Condition 2 and Condition 1 (p > 0.05).Conclusions: There could be dose-response between frequency of breaks in sedentary time and glucose. Interrupting sedentary time every 15 min could produce better glucose control.
AB - Objectives: This study aimed to investigate dose-response between frequency of breaks in sedentary time and glucose control. Design: Randomised three-treatment, two-period balanced incomplete block trial.Methods: Twelve adults with type 2 diabetes (age, 60 ± 11 years; body mass index, 30.2 ± 4.7 kg/m2) participated in two of the following treatment conditions: sitting for 7 h interrupted by 3 min light-intensity walking breaks every (1) 60 min (Condition 1), (2) 30 min (Condition 2), and (3) 15 min (Condition 3). Postprandial glucose incremental area under the curves (iAUCs) and 21-h glucose total area under the curve (AUC) were measured using continuous glucose monitoring. Standardised meals were provided.Results: Compared with Condition 1 (6.7 ± 0.8 mmol L-1·3.5 h-1), post-breakfast glucose iAUC was reduced for Condition 3 (3.5 ± 0.9 mmol L-1·3.5 h-1, p < 0.04). Post-lunch glucose iAUC was lower in Condition 3 (1.3 ± 0.9 mmol L-1·3.5 h-1, p < 0.03) and Condition 2 (2.1 ± 0.7 mmol L-1·3.5 h-1, p < 0.05) relative to Condition 1 (4.6 ± 0.8 mmol L-1·3.5 h-1). Condition 3 (1.0 ± 0.7 mmol L-1·3.5 h-1, p = 0.02) and Condition 2 (1.6 ± 0.6 mmol L-1·3.5 h-1, p < 0.04) attenuated post-dinner glucose iAUC compared with Condition 1 (4.0 ± 0.7 mmol L-1·3.5 h-1). Cumulative 10.5-h postprandial glucose iAUC was lower in Condition 3 than Condition 1 (p = 0.02). Condition 3 reduced 21-h glucose AUC compared with Condition 1 (p < 0.001) and Condition 2 (p = 0.002). However, post-breakfast glucose iAUC, cumulative 10.5-h postprandial glucose iAUC and 21-h glucose AUC were not different between Condition 2 and Condition 1 (p > 0.05).Conclusions: There could be dose-response between frequency of breaks in sedentary time and glucose. Interrupting sedentary time every 15 min could produce better glucose control.
KW - diabetes mellitus
KW - glucose
KW - sedentary lifestyle
KW - exercise
U2 - 10.1016/j.jsams.2019.01.017
DO - 10.1016/j.jsams.2019.01.017
M3 - Article
VL - 22
SP - 808
EP - 813
JO - Journal of Science and Medicine in Sport
JF - Journal of Science and Medicine in Sport
SN - 1440-2440
IS - 7
ER -