Dose-response between frequency of breaks in sedentary time and glucose control in type 2 diabetes: a proof of concept study

Aye C. Paing, Kathryn A. McMillan, Alison F. Kirk, Andrew Collier, Allan Hewitt, Sebastien F.M. Chastin

Research output: Contribution to journalArticle

Abstract

Objectives: This study aimed to investigate dose-response between frequency of breaks in sedentary time and glucose control.
Design: Randomised three-treatment, two-period balanced incomplete block trial.
Methods: Twelve adults with type 2 diabetes (age, 60 ± 11 years; body mass index, 30.2 ± 4.7 kg/m2) participated in two of the following treatment conditions: sitting for 7 h interrupted by 3 min light-intensity walking breaks every (1) 60 min (Condition 1), (2) 30 min (Condition 2), and (3) 15 min (Condition 3). Postprandial glucose incremental area under the curves (iAUCs) and 21-h glucose total area under the curve (AUC) were measured using continuous glucose monitoring. Standardised meals were provided.
Results: Compared with Condition 1 (6.7 ± 0.8 mmol L-1·3.5 h-1), post-breakfast glucose iAUC was reduced for Condition 3 (3.5 ± 0.9 mmol L-1·3.5 h-1, p < 0.04). Post-lunch glucose iAUC was lower in Condition 3 (1.3 ± 0.9 mmol L-1·3.5 h-1, p < 0.03) and Condition 2 (2.1 ± 0.7 mmol L-1·3.5 h-1, p < 0.05) relative to Condition 1 (4.6 ± 0.8 mmol L-1·3.5 h-1). Condition 3 (1.0 ± 0.7 mmol L-1·3.5 h-1, p = 0.02) and Condition 2 (1.6 ± 0.6 mmol L-1·3.5 h-1, p < 0.04) attenuated post-dinner glucose iAUC compared with Condition 1 (4.0 ± 0.7 mmol L-1·3.5 h-1). Cumulative 10.5-h postprandial glucose iAUC was lower in Condition 3 than Condition 1 (p = 0.02). Condition 3 reduced 21-h glucose AUC compared with Condition 1 (p < 0.001) and Condition 2 (p = 0.002). However, post-breakfast glucose iAUC, cumulative 10.5-h postprandial glucose iAUC and 21-h glucose AUC were not different between Condition 2 and Condition 1 (p > 0.05).

Conclusions: There could be dose-response between frequency of breaks in sedentary time and glucose. Interrupting sedentary time every 15 min could produce better glucose control.
Original languageEnglish
Pages (from-to)808-813
Number of pages6
JournalJournal of Science and Medicine in Sport
Volume22
Issue number7
Early online date31 Jan 2019
DOIs
Publication statusPublished - Jul 2019

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Type 2 Diabetes Mellitus
Glucose
Area Under Curve
Breakfast
Walking
Meals
Body Mass Index
Light

Keywords

  • diabetes mellitus
  • glucose
  • sedentary lifestyle
  • exercise

Cite this

Paing, Aye C. ; McMillan, Kathryn A. ; Kirk, Alison F. ; Collier, Andrew ; Hewitt, Allan ; Chastin, Sebastien F.M. / Dose-response between frequency of breaks in sedentary time and glucose control in type 2 diabetes: a proof of concept study. In: Journal of Science and Medicine in Sport. 2019 ; Vol. 22, No. 7. pp. 808-813.
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abstract = "Objectives: This study aimed to investigate dose-response between frequency of breaks in sedentary time and glucose control. Design: Randomised three-treatment, two-period balanced incomplete block trial.Methods: Twelve adults with type 2 diabetes (age, 60 ± 11 years; body mass index, 30.2 ± 4.7 kg/m2) participated in two of the following treatment conditions: sitting for 7 h interrupted by 3 min light-intensity walking breaks every (1) 60 min (Condition 1), (2) 30 min (Condition 2), and (3) 15 min (Condition 3). Postprandial glucose incremental area under the curves (iAUCs) and 21-h glucose total area under the curve (AUC) were measured using continuous glucose monitoring. Standardised meals were provided.Results: Compared with Condition 1 (6.7 ± 0.8 mmol L-1·3.5 h-1), post-breakfast glucose iAUC was reduced for Condition 3 (3.5 ± 0.9 mmol L-1·3.5 h-1, p < 0.04). Post-lunch glucose iAUC was lower in Condition 3 (1.3 ± 0.9 mmol L-1·3.5 h-1, p < 0.03) and Condition 2 (2.1 ± 0.7 mmol L-1·3.5 h-1, p < 0.05) relative to Condition 1 (4.6 ± 0.8 mmol L-1·3.5 h-1). Condition 3 (1.0 ± 0.7 mmol L-1·3.5 h-1, p = 0.02) and Condition 2 (1.6 ± 0.6 mmol L-1·3.5 h-1, p < 0.04) attenuated post-dinner glucose iAUC compared with Condition 1 (4.0 ± 0.7 mmol L-1·3.5 h-1). Cumulative 10.5-h postprandial glucose iAUC was lower in Condition 3 than Condition 1 (p = 0.02). Condition 3 reduced 21-h glucose AUC compared with Condition 1 (p < 0.001) and Condition 2 (p = 0.002). However, post-breakfast glucose iAUC, cumulative 10.5-h postprandial glucose iAUC and 21-h glucose AUC were not different between Condition 2 and Condition 1 (p > 0.05).Conclusions: There could be dose-response between frequency of breaks in sedentary time and glucose. Interrupting sedentary time every 15 min could produce better glucose control.",
keywords = "diabetes mellitus , glucose, sedentary lifestyle, exercise",
author = "Paing, {Aye C.} and McMillan, {Kathryn A.} and Kirk, {Alison F.} and Andrew Collier and Allan Hewitt and Chastin, {Sebastien F.M.}",
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Dose-response between frequency of breaks in sedentary time and glucose control in type 2 diabetes: a proof of concept study. / Paing, Aye C.; McMillan, Kathryn A.; Kirk, Alison F.; Collier, Andrew; Hewitt, Allan; Chastin, Sebastien F.M.

In: Journal of Science and Medicine in Sport, Vol. 22, No. 7, 07.2019, p. 808-813.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dose-response between frequency of breaks in sedentary time and glucose control in type 2 diabetes: a proof of concept study

AU - Paing, Aye C.

AU - McMillan, Kathryn A.

AU - Kirk, Alison F.

AU - Collier, Andrew

AU - Hewitt, Allan

AU - Chastin, Sebastien F.M.

N1 - Acceptance in SAN AAM version queried. 28/01/19 DC. Set the file to closed visibility - author confirmed will change manuscript 28/1/19 ET ^AAM rec'd 13/3/19; 12m embargo

PY - 2019/7

Y1 - 2019/7

N2 - Objectives: This study aimed to investigate dose-response between frequency of breaks in sedentary time and glucose control. Design: Randomised three-treatment, two-period balanced incomplete block trial.Methods: Twelve adults with type 2 diabetes (age, 60 ± 11 years; body mass index, 30.2 ± 4.7 kg/m2) participated in two of the following treatment conditions: sitting for 7 h interrupted by 3 min light-intensity walking breaks every (1) 60 min (Condition 1), (2) 30 min (Condition 2), and (3) 15 min (Condition 3). Postprandial glucose incremental area under the curves (iAUCs) and 21-h glucose total area under the curve (AUC) were measured using continuous glucose monitoring. Standardised meals were provided.Results: Compared with Condition 1 (6.7 ± 0.8 mmol L-1·3.5 h-1), post-breakfast glucose iAUC was reduced for Condition 3 (3.5 ± 0.9 mmol L-1·3.5 h-1, p < 0.04). Post-lunch glucose iAUC was lower in Condition 3 (1.3 ± 0.9 mmol L-1·3.5 h-1, p < 0.03) and Condition 2 (2.1 ± 0.7 mmol L-1·3.5 h-1, p < 0.05) relative to Condition 1 (4.6 ± 0.8 mmol L-1·3.5 h-1). Condition 3 (1.0 ± 0.7 mmol L-1·3.5 h-1, p = 0.02) and Condition 2 (1.6 ± 0.6 mmol L-1·3.5 h-1, p < 0.04) attenuated post-dinner glucose iAUC compared with Condition 1 (4.0 ± 0.7 mmol L-1·3.5 h-1). Cumulative 10.5-h postprandial glucose iAUC was lower in Condition 3 than Condition 1 (p = 0.02). Condition 3 reduced 21-h glucose AUC compared with Condition 1 (p < 0.001) and Condition 2 (p = 0.002). However, post-breakfast glucose iAUC, cumulative 10.5-h postprandial glucose iAUC and 21-h glucose AUC were not different between Condition 2 and Condition 1 (p > 0.05).Conclusions: There could be dose-response between frequency of breaks in sedentary time and glucose. Interrupting sedentary time every 15 min could produce better glucose control.

AB - Objectives: This study aimed to investigate dose-response between frequency of breaks in sedentary time and glucose control. Design: Randomised three-treatment, two-period balanced incomplete block trial.Methods: Twelve adults with type 2 diabetes (age, 60 ± 11 years; body mass index, 30.2 ± 4.7 kg/m2) participated in two of the following treatment conditions: sitting for 7 h interrupted by 3 min light-intensity walking breaks every (1) 60 min (Condition 1), (2) 30 min (Condition 2), and (3) 15 min (Condition 3). Postprandial glucose incremental area under the curves (iAUCs) and 21-h glucose total area under the curve (AUC) were measured using continuous glucose monitoring. Standardised meals were provided.Results: Compared with Condition 1 (6.7 ± 0.8 mmol L-1·3.5 h-1), post-breakfast glucose iAUC was reduced for Condition 3 (3.5 ± 0.9 mmol L-1·3.5 h-1, p < 0.04). Post-lunch glucose iAUC was lower in Condition 3 (1.3 ± 0.9 mmol L-1·3.5 h-1, p < 0.03) and Condition 2 (2.1 ± 0.7 mmol L-1·3.5 h-1, p < 0.05) relative to Condition 1 (4.6 ± 0.8 mmol L-1·3.5 h-1). Condition 3 (1.0 ± 0.7 mmol L-1·3.5 h-1, p = 0.02) and Condition 2 (1.6 ± 0.6 mmol L-1·3.5 h-1, p < 0.04) attenuated post-dinner glucose iAUC compared with Condition 1 (4.0 ± 0.7 mmol L-1·3.5 h-1). Cumulative 10.5-h postprandial glucose iAUC was lower in Condition 3 than Condition 1 (p = 0.02). Condition 3 reduced 21-h glucose AUC compared with Condition 1 (p < 0.001) and Condition 2 (p = 0.002). However, post-breakfast glucose iAUC, cumulative 10.5-h postprandial glucose iAUC and 21-h glucose AUC were not different between Condition 2 and Condition 1 (p > 0.05).Conclusions: There could be dose-response between frequency of breaks in sedentary time and glucose. Interrupting sedentary time every 15 min could produce better glucose control.

KW - diabetes mellitus

KW - glucose

KW - sedentary lifestyle

KW - exercise

U2 - 10.1016/j.jsams.2019.01.017

DO - 10.1016/j.jsams.2019.01.017

M3 - Article

VL - 22

SP - 808

EP - 813

JO - Journal of Science and Medicine in Sport

JF - Journal of Science and Medicine in Sport

SN - 1440-2440

IS - 7

ER -