TY - JOUR
T1 - Differential susceptibility of Cx26 mutations associated with epidermal dysplasias to peptidoglycan derived from Staphylococcus aureus and Staphylococcus epidermidis
AU - Donnelly, Steven
AU - English, Grant
AU - de Zwart-Storm, Eugene A.
AU - Lang, Susan
AU - van Steensel, Maurice A.M.
AU - Martin, Patricia E.
PY - 2012/8
Y1 - 2012/8
N2 - Mutations in Connexin26 (Cx26) give rise to a spectrum of dominantly inherited hyperproliferating skin disorders, the severest being keratitis–ichthyosis–deafness (KID) syndrome, an inflammatory skin disorder, with patients prone to opportunistic infections. We compared the effects of peptidoglycan (PGN) extracted from the skin commensal Staphylococcus epidermidis and the opportunistic pathogen Staphylococcus aureus on interleukin-6 and connexin expression in HaCaT cells (a keratinocyte cell line) and connexin channel activity in HaCaT and HeLa (connexin deficient) cells transfected to express KID and non-KID Cx26 mutations.
AB - Mutations in Connexin26 (Cx26) give rise to a spectrum of dominantly inherited hyperproliferating skin disorders, the severest being keratitis–ichthyosis–deafness (KID) syndrome, an inflammatory skin disorder, with patients prone to opportunistic infections. We compared the effects of peptidoglycan (PGN) extracted from the skin commensal Staphylococcus epidermidis and the opportunistic pathogen Staphylococcus aureus on interleukin-6 and connexin expression in HaCaT cells (a keratinocyte cell line) and connexin channel activity in HaCaT and HeLa (connexin deficient) cells transfected to express KID and non-KID Cx26 mutations.
KW - epidermal dysplasia
KW - peptidoglycan
KW - Staphylococcus aureus
KW - Staphylococcus epidermidis
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84863780787&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0625.2012.01521.x
DO - 10.1111/j.1600-0625.2012.01521.x
M3 - Article
AN - SCOPUS:84863780787
VL - 21
SP - 592
EP - 598
JO - Experimental Dermatology
JF - Experimental Dermatology
IS - 8
ER -