Abstract
Environmental oestrogens are responsible for adverse effects in fish that affect reproduction. Availability of model fish to study the differential effects of endogenous and exogenous oestrogens and to test for oestrogenic activity of chemicals would be advantageous. Zebrafish could provide such a model, but the organisation and expression of vitellogenins (VTGs) and oestrogen receptors (ERs) are not completely understood. VTGs are synthesised in the liver and provide a sensitive biomarker of oestrogenic activity since they are thought to be under the regulation of the ER.
| Original language | English |
|---|---|
| Pages (from-to) | 625-630 |
| Number of pages | 6 |
| Journal | Analytical and Bioanalytical Chemistry |
| Volume | 396 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Jan 2010 |
Keywords
- oestrogen receptor genes
- vitellogenin
- zebrafish
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Meng, X., Bartholomew, C., & Craft, J. A. (2010). Differential expression of vitellogenin and oestrogen receptor genes in the liver of zebrafish, Danio Rerio. Analytical and Bioanalytical Chemistry, 396(2), 625-630. https://doi.org/10.1007/s00216-009-3112-2