Abstract
Environmental oestrogens are responsible for adverse effects in fish that affect reproduction. Availability of model fish to study the differential effects of endogenous and exogenous oestrogens and to test for oestrogenic activity of chemicals would be advantageous. Zebrafish could provide such a model, but the organisation and expression of vitellogenins (VTGs) and oestrogen receptors (ERs) are not completely understood. VTGs are synthesised in the liver and provide a sensitive biomarker of oestrogenic activity since they are thought to be under the regulation of the ER.
| Original language | English |
|---|---|
| Pages (from-to) | 625-630 |
| Number of pages | 6 |
| Journal | Analytical and Bioanalytical Chemistry |
| Volume | 396 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Jan 2010 |
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Keywords
- oestrogen receptor genes
- vitellogenin
- zebrafish
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Differential expression of vitellogenin and oestrogen receptor genes in the liver of zebrafish, Danio Rerio. / Meng, Xiang; Bartholomew, Chris; Craft, John A.
In: Analytical and Bioanalytical Chemistry, Vol. 396, No. 2, 01.01.2010, p. 625-630.Research output: Contribution to journal › Article
TY - JOUR
T1 - Differential expression of vitellogenin and oestrogen receptor genes in the liver of zebrafish, Danio Rerio
AU - Meng, Xiang
AU - Bartholomew, Chris
AU - Craft, John A.
N1 - Originally published in: Analytical and Bioanalytical Chemistry (2010), 396 (2), pp.625-630.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Environmental oestrogens are responsible for adverse effects in fish that affect reproduction. Availability of model fish to study the differential effects of endogenous and exogenous oestrogens and to test for oestrogenic activity of chemicals would be advantageous. Zebrafish could provide such a model, but the organisation and expression of vitellogenins (VTGs) and oestrogen receptors (ERs) are not completely understood. VTGs are synthesised in the liver and provide a sensitive biomarker of oestrogenic activity since they are thought to be under the regulation of the ER.
AB - Environmental oestrogens are responsible for adverse effects in fish that affect reproduction. Availability of model fish to study the differential effects of endogenous and exogenous oestrogens and to test for oestrogenic activity of chemicals would be advantageous. Zebrafish could provide such a model, but the organisation and expression of vitellogenins (VTGs) and oestrogen receptors (ERs) are not completely understood. VTGs are synthesised in the liver and provide a sensitive biomarker of oestrogenic activity since they are thought to be under the regulation of the ER.
KW - oestrogen receptor genes
KW - vitellogenin
KW - zebrafish
U2 - 10.1007/s00216-009-3112-2
DO - 10.1007/s00216-009-3112-2
M3 - Article
VL - 396
SP - 625
EP - 630
JO - Analytical and Bioanalytical Chemistry
JF - Analytical and Bioanalytical Chemistry
SN - 1618-2642
IS - 2
ER -