Differential expression of vitellogenin and oestrogen receptor genes in the liver of zebrafish, Danio Rerio

Xiang Meng, Chris Bartholomew, John A. Craft

Research output: Contribution to journalArticle

Abstract

Environmental oestrogens are responsible for adverse effects in fish that affect reproduction. Availability of model fish to study the differential effects of endogenous and exogenous oestrogens and to test for oestrogenic activity of chemicals would be advantageous. Zebrafish could provide such a model, but the organisation and expression of vitellogenins (VTGs) and oestrogen receptors (ERs) are not completely understood. VTGs are synthesised in the liver and provide a sensitive biomarker of oestrogenic activity since they are thought to be under the regulation of the ER.

Original languageEnglish
Pages (from-to)625-630
Number of pages6
JournalAnalytical and Bioanalytical Chemistry
Volume396
Issue number2
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • oestrogen receptor genes
  • vitellogenin
  • zebrafish

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