Differential expression of vitellogenin and oestrogen receptor genes in the liver of zebrafish, Danio Rerio

Xiang Meng; Chris Bartholomew; John A. Craft

doi:10.1007/s00216-009-3112-2

Differential expression of vitellogenin and oestrogen receptor genes in the liver of zebrafish, Danio Rerio

Xiang Meng, Chris Bartholomew, John A. Craft

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Environmental oestrogens are responsible for adverse effects in fish that affect reproduction. Availability of model fish to study the differential effects of endogenous and exogenous oestrogens and to test for oestrogenic activity of chemicals would be advantageous. Zebrafish could provide such a model, but the organisation and expression of vitellogenins (VTGs) and oestrogen receptors (ERs) are not completely understood. VTGs are synthesised in the liver and provide a sensitive biomarker of oestrogenic activity since they are thought to be under the regulation of the ER.

Original language	English
Pages (from-to)	625-630
Number of pages	6
Journal	Analytical and Bioanalytical Chemistry
Volume	396
Issue number	2
DOIs	https://doi.org/10.1007/s00216-009-3112-2
Publication status	Published - 1 Jan 2010

Keywords

oestrogen receptor genes
vitellogenin
zebrafish

Documents and Links

10.1007/s00216-009-3112-2

http://researchonline.gcu.ac.uk/sls/220

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abstract = "Environmental oestrogens are responsible for adverse effects in fish that affect reproduction. Availability of model fish to study the differential effects of endogenous and exogenous oestrogens and to test for oestrogenic activity of chemicals would be advantageous. Zebrafish could provide such a model, but the organisation and expression of vitellogenins (VTGs) and oestrogen receptors (ERs) are not completely understood. VTGs are synthesised in the liver and provide a sensitive biomarker of oestrogenic activity since they are thought to be under the regulation of the ER.",

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T1 - Differential expression of vitellogenin and oestrogen receptor genes in the liver of zebrafish, Danio Rerio

AU - Meng, Xiang

AU - Bartholomew, Chris

AU - Craft, John A.

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PY - 2010/1/1

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N2 - Environmental oestrogens are responsible for adverse effects in fish that affect reproduction. Availability of model fish to study the differential effects of endogenous and exogenous oestrogens and to test for oestrogenic activity of chemicals would be advantageous. Zebrafish could provide such a model, but the organisation and expression of vitellogenins (VTGs) and oestrogen receptors (ERs) are not completely understood. VTGs are synthesised in the liver and provide a sensitive biomarker of oestrogenic activity since they are thought to be under the regulation of the ER.

AB - Environmental oestrogens are responsible for adverse effects in fish that affect reproduction. Availability of model fish to study the differential effects of endogenous and exogenous oestrogens and to test for oestrogenic activity of chemicals would be advantageous. Zebrafish could provide such a model, but the organisation and expression of vitellogenins (VTGs) and oestrogen receptors (ERs) are not completely understood. VTGs are synthesised in the liver and provide a sensitive biomarker of oestrogenic activity since they are thought to be under the regulation of the ER.

KW - oestrogen receptor genes

KW - vitellogenin

KW - zebrafish

U2 - 10.1007/s00216-009-3112-2

DO - 10.1007/s00216-009-3112-2

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JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

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