Diagnosis of hepatitis C virus infection in Scotland's injecting drug user population

S.A. McDonald, S.J. Hutchinson, P.R. Mills, S.M. Bird, C. Robertson, J.F. Dillon, A. Springbett, D.J. Goldberg

Research output: Contribution to journalArticle

Abstract

We estimated the extent of undiagnosed hepatitis C virus (HCV) infection in injecting drug users (IDUs) in Scotland. We used record-linkage to determine HCV diagnosis status for 41 062 current/former IDUs attending drug treatment and support services between 1 April 1995 and 31 March 2006; the extent of undiagnosed HCV infection was estimated by comparing the number HCV-diagnosed to the number HCV-infected (estimated from an unlinked anonymous testing survey of 2141 current/former IDUs). In all, 9145 IDUs (22%) were diagnosed HCV antibody-positive since first attendance at drug services (diagnosis rate of 33·6/1000 person-years, 95% CI 32·7–34·4). By 31 March 2006, of the 19 632 current/former IDUs who had attended drug services and were determined to be living with HCV, an estimated 58% (95% CI 45–62) had not been HCV-diagnosed. It is essential that the deployment of resources for identifying at-risk IDUs with a view to offering antiviral therapy is guided by evidence.
Original languageEnglish
Pages (from-to)393-402
Number of pages10
JournalEpidemiology and Infection
Volume138
Issue number3
DOIs
Publication statusPublished - Mar 2010

Keywords

  • diagnosis
  • hepatitis C
  • antiviral therapy
  • injecting drug users

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