Abstract
Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic drugs such as dexfenfluramine (Dfen) have been associated with the development of PAH. Dfen mediates PAH via a serotonergic mechanism and we have shown serotonin to up-regulate expression of CYP1B1 in human pulmonary artery smooth muscle cells (PASMCs). Thus here we assess the role of CYP1B1 in the development of Dfen-induced PAH.
Original language | English |
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Pages (from-to) | 24-34 |
Number of pages | 11 |
Journal | Cardiovascular Research |
Volume | 99 |
Issue number | 1 |
Early online date | 20 Mar 2013 |
DOIs | |
Publication status | Published - Jul 2013 |
Keywords
- arterial hypertension
- oestrogen
- anorectic drugs