Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension

Yvonne Dempsie; Neil MacRitchie; Kevin White; Ian Morecroft; Audrey F. Wright; Margaret  Nilsen; Lynn Loughlin; Kirsty M. Mair; Margaret R. MacLean

doi:10.1093/cvr/cvt064

Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension

Yvonne Dempsie, Neil MacRitchie, Kevin White, Ian Morecroft, Audrey F. Wright, Margaret Nilsen, Lynn Loughlin, Kirsty M. Mair, Margaret R. MacLean

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic drugs such as dexfenfluramine (Dfen) have been associated with the development of PAH. Dfen mediates PAH via a serotonergic mechanism and we have shown serotonin to up-regulate expression of CYP1B1 in human pulmonary artery smooth muscle cells (PASMCs). Thus here we assess the role of CYP1B1 in the development of Dfen-induced PAH.

Original language	English
Pages (from-to)	24-34
Number of pages	11
Journal	Cardiovascular Research
Volume	99
Issue number	1
Early online date	20 Mar 2013
DOIs	https://doi.org/10.1093/cvr/cvt064
Publication status	Published - Jul 2013

Keywords

arterial hypertension
oestrogen
anorectic drugs

Documents and Links

10.1093/cvr/cvt064

Publication in Scopus

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title = "Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension",

abstract = "Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic drugs such as dexfenfluramine (Dfen) have been associated with the development of PAH. Dfen mediates PAH via a serotonergic mechanism and we have shown serotonin to up-regulate expression of CYP1B1 in human pulmonary artery smooth muscle cells (PASMCs). Thus here we assess the role of CYP1B1 in the development of Dfen-induced PAH. ",

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language = "English",

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journal = "Cardiovascular Research",

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Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. / Dempsie, Yvonne; MacRitchie, Neil; White, Kevin; Morecroft, Ian; Wright, Audrey F.; Nilsen, Margaret ; Loughlin, Lynn; Mair, Kirsty M.; MacLean, Margaret R.

In: Cardiovascular Research, Vol. 99, No. 1, 07.2013, p. 24-34.

Research output: Contribution to journal › Article › peer-review

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T1 - Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension

AU - Dempsie, Yvonne

AU - MacRitchie, Neil

AU - White, Kevin

AU - Morecroft, Ian

AU - Wright, Audrey F.

AU - Nilsen, Margaret

AU - Loughlin, Lynn

AU - Mair, Kirsty M.

AU - MacLean, Margaret R.

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AB - Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic drugs such as dexfenfluramine (Dfen) have been associated with the development of PAH. Dfen mediates PAH via a serotonergic mechanism and we have shown serotonin to up-regulate expression of CYP1B1 in human pulmonary artery smooth muscle cells (PASMCs). Thus here we assess the role of CYP1B1 in the development of Dfen-induced PAH.

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