Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females

Yvonne Dempsie; Margaret  Nilsen; Kevin White; Kirsty M Mair; Noona Ambartsumian; Marlene Rabinovitch; Margaret R MacLean

doi:10.1186/1465-9921-12-159

Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females

Yvonne Dempsie, Margaret Nilsen, Kevin White, Kirsty M Mair, Noona Ambartsumian, Marlene Rabinovitch, Margaret R MacLean

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH.

Original language	English
Journal	Respiratory Research
Volume	12
DOIs	https://doi.org/10.1186/1465-9921-12-159
Publication status	Published - Dec 2011

Keywords

pulmonary arterial hypertension
PAH

Documents and Links

10.1186/1465-9921-12-159

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title = "Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females",

abstract = "Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH. ",

keywords = "pulmonary arterial hypertension, PAH",

author = "Yvonne Dempsie and Margaret Nilsen and Kevin White and Mair, {Kirsty M} and Noona Ambartsumian and Marlene Rabinovitch and MacLean, {Margaret R}",

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AU - Dempsie, Yvonne

AU - Nilsen, Margaret

AU - White, Kevin

AU - Mair, Kirsty M

AU - Ambartsumian, Noona

AU - Rabinovitch, Marlene

AU - MacLean, Margaret R

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N2 - Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH.

AB - Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH.

KW - pulmonary arterial hypertension

KW - PAH

U2 - 10.1186/1465-9921-12-159

DO - 10.1186/1465-9921-12-159

M3 - Article

VL - 12

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

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