Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females

Yvonne Dempsie, Margaret Nilsen, Kevin White, Kirsty M Mair, Noona Ambartsumian, Marlene Rabinovitch, Margaret R MacLean

Research output: Contribution to journalArticle

Abstract

Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH.
Original languageEnglish
JournalRespiratory Research
Volume12
DOIs
Publication statusPublished - Dec 2011

    Fingerprint

Keywords

  • pulmonary arterial hypertension
  • PAH

Cite this