Abstract
Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH.
Original language | English |
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Journal | Respiratory Research |
Volume | 12 |
DOIs | |
Publication status | Published - Dec 2011 |
Keywords
- pulmonary arterial hypertension
- PAH