Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females

Yvonne Dempsie; Margaret  Nilsen; Kevin White; Kirsty M Mair; Noona Ambartsumian; Marlene Rabinovitch; Margaret R MacLean

doi:10.1186/1465-9921-12-159

Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females

Yvonne Dempsie, Margaret Nilsen, Kevin White, Kirsty M Mair, Noona Ambartsumian, Marlene Rabinovitch, Margaret R MacLean

Biological and Biomedical Sciences

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Abstract

Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH.

Original language	English
Journal	Respiratory Research
Volume	12
DOIs	https://doi.org/10.1186/1465-9921-12-159
Publication status	Published - Dec 2011

Keywords

pulmonary arterial hypertension
PAH

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10.1186/1465-9921-12-159

Dempsie, Y. et al (2011) Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females
© 2011 Dempsie et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 1.79 MBLicence: CC BY

Cite this

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abstract = "Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH. ",

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AU - Dempsie, Yvonne

AU - Nilsen, Margaret

AU - White, Kevin

AU - Mair, Kirsty M

AU - Ambartsumian, Noona

AU - Rabinovitch, Marlene

AU - MacLean, Margaret R

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N2 - Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH.

AB - Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH.

KW - pulmonary arterial hypertension

KW - PAH

U2 - 10.1186/1465-9921-12-159

DO - 10.1186/1465-9921-12-159

M3 - Article

SN - 1465-993X

VL - 12

JO - Respiratory Research

JF - Respiratory Research

ER -

Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females

Abstract

Keywords

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