Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH.
- pulmonary arterial hypertension
Dempsie, Y., Nilsen, M., White, K., Mair, K. M., Ambartsumian, N., Rabinovitch, M., & MacLean, M. R. (2011). Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. Respiratory Research, 12. https://doi.org/10.1186/1465-9921-12-159