Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females

Yvonne Dempsie, Margaret Nilsen, Kevin White, Kirsty M Mair, Noona Ambartsumian, Marlene Rabinovitch, Margaret R MacLean

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Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a role in the gender bias associated with PAH.
Original languageEnglish
JournalRespiratory Research
Publication statusPublished - Dec 2011



  • pulmonary arterial hypertension
  • PAH

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