Development of a polymicrobial host-bacterial interface biofilm model for bacterial vaginosis

William Johnston; Ryan Kean

doi:10.1016/j.anaerobe.2025.102952

Development of a polymicrobial host-bacterial interface biofilm model for bacterial vaginosis

William Johnston, Ryan Kean^*

^*Corresponding author for this work

Department of Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Bacterial vaginosis (BV) is characterised by a polymicrobial biofilm forming on the vaginal epithelium. In this study, we have developed a host-pathogen model of BV to replicate disease. We demonstrated tissue colonisation by four key vaginal pathobionts that formed metronidazole tolerant biofilms, with subtle changes in cytotoxicity and inflammation.

Original language	English
Article number	102952
Number of pages	4
Journal	Anaerobe
Volume	93
Early online date	8 Mar 2025
DOIs	https://doi.org/10.1016/j.anaerobe.2025.102952
Publication status	E-pub ahead of print - 8 Mar 2025

ASJC Scopus subject areas

Microbiology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Documents and Links

10.1016/j.anaerobe.2025.102952

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Author accepted manuscript
Author accepted manuscript, 328 KB
Licence: CC BY-NC-ND
Embargo ends: 8/03/26

Cite this

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abstract = "Bacterial vaginosis (BV) is characterised by a polymicrobial biofilm forming on the vaginal epithelium. In this study, we have developed a host-pathogen model of BV to replicate disease. We demonstrated tissue colonisation by four key vaginal pathobionts that formed metronidazole tolerant biofilms, with subtle changes in cytotoxicity and inflammation.",

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AB - Bacterial vaginosis (BV) is characterised by a polymicrobial biofilm forming on the vaginal epithelium. In this study, we have developed a host-pathogen model of BV to replicate disease. We demonstrated tissue colonisation by four key vaginal pathobionts that formed metronidazole tolerant biofilms, with subtle changes in cytotoxicity and inflammation.

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DO - 10.1016/j.anaerobe.2025.102952

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JO - Anaerobe

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Development of a polymicrobial host-bacterial interface biofilm model for bacterial vaginosis

Abstract

ASJC Scopus subject areas

UN SDGs

Documents and Links

Embargoed Document

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Cite this