Abstract
Terminally differentiating keratinocytes actively synthesize and accumulate cholesterol, which is a key constituent of intercellular lipid lamellae which contribute to the epidermal permeability barrier. While the pathway for cholesterol biosynthesis is established, intracellular transport mechanisms for this lipid are poorly understood, despite their importance in regulating organelle sterol content, keratinocyte differentiation status and the activity of lipid-responsive transcription factors involved in skin health, repair and disease. Recent data implicate proteins containing a steroidogenic acute regulatory protein (StAR)- related lipid transfer (START) domain in cellular cholesterol homeostasis.
Original language | English |
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Journal | British Journal of Dermatology |
DOIs | |
Publication status | Published - 1 Feb 2011 |
Keywords
- cholesterol homeostasis
- STARD4