Cytosolic StAR-related lipid transfer domain 4 (STARD4) protein influences keratinocyte lipid phenotype and differentiation status

H. M. Elbadawy, Faye Borthwick, Catherine Wright, Patricia E.M. Martin, Annette Graham

Research output: Contribution to journalArticle

Abstract

Terminally differentiating keratinocytes actively synthesize and accumulate cholesterol, which is a key constituent of intercellular lipid lamellae which contribute to the epidermal permeability barrier. While the pathway for cholesterol biosynthesis is established, intracellular transport mechanisms for this lipid are poorly understood, despite their importance in regulating organelle sterol content, keratinocyte differentiation status and the activity of lipid-responsive transcription factors involved in skin health, repair and disease. Recent data implicate proteins containing a steroidogenic acute regulatory protein (StAR)- related lipid transfer (START) domain in cellular cholesterol homeostasis.

Original languageEnglish
JournalBritish Journal of Dermatology
DOIs
Publication statusPublished - 1 Feb 2011

Keywords

  • cholesterol homeostasis
  • STARD4

Fingerprint Dive into the research topics of 'Cytosolic StAR-related lipid transfer domain 4 (STARD4) protein influences keratinocyte lipid phenotype and differentiation status'. Together they form a unique fingerprint.

  • Cite this