Cytosolic StAR-related lipid transfer domain 4 (STARD4) protein influences keratinocyte lipid phenotype and differentiation status

H. M. Elbadawy; Faye Borthwick; Catherine Wright; Patricia E.M. Martin; Annette Graham

doi:10.1111/j.1365-2133.2010.10102.x

Cytosolic StAR-related lipid transfer domain 4 (STARD4) protein influences keratinocyte lipid phenotype and differentiation status

H. M. Elbadawy, Faye Borthwick, Catherine Wright, Patricia E.M. Martin, Annette Graham

Biological and Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

Terminally differentiating keratinocytes actively synthesize and accumulate cholesterol, which is a key constituent of intercellular lipid lamellae which contribute to the epidermal permeability barrier. While the pathway for cholesterol biosynthesis is established, intracellular transport mechanisms for this lipid are poorly understood, despite their importance in regulating organelle sterol content, keratinocyte differentiation status and the activity of lipid-responsive transcription factors involved in skin health, repair and disease. Recent data implicate proteins containing a steroidogenic acute regulatory protein (StAR)- related lipid transfer (START) domain in cellular cholesterol homeostasis.

Original language	English
Journal	British Journal of Dermatology
DOIs	https://doi.org/10.1111/j.1365-2133.2010.10102.x
Publication status	Published - 1 Feb 2011

Keywords

cholesterol homeostasis
STARD4

Documents and Links

10.1111/j.1365-2133.2010.10102.x

http://researchonline.gcu.ac.uk/sls/255

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Elbadawy, H. M., Borthwick, F., Wright, C., Martin, P. E. M., & Graham, A. (2011). Cytosolic StAR-related lipid transfer domain 4 (STARD4) protein influences keratinocyte lipid phenotype and differentiation status. British Journal of Dermatology. https://doi.org/10.1111/j.1365-2133.2010.10102.x

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abstract = "Terminally differentiating keratinocytes actively synthesize and accumulate cholesterol, which is a key constituent of intercellular lipid lamellae which contribute to the epidermal permeability barrier. While the pathway for cholesterol biosynthesis is established, intracellular transport mechanisms for this lipid are poorly understood, despite their importance in regulating organelle sterol content, keratinocyte differentiation status and the activity of lipid-responsive transcription factors involved in skin health, repair and disease. Recent data implicate proteins containing a steroidogenic acute regulatory protein (StAR)- related lipid transfer (START) domain in cellular cholesterol homeostasis.",

keywords = "cholesterol homeostasis, STARD4",

author = "Elbadawy, {H. M.} and Faye Borthwick and Catherine Wright and Martin, {Patricia E.M.} and Annette Graham",

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AU - Elbadawy, H. M.

AU - Borthwick, Faye

AU - Wright, Catherine

AU - Martin, Patricia E.M.

AU - Graham, Annette

N1 - Originally published in: British Journal of Dermatology (2011), electronically available ahead of print.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Terminally differentiating keratinocytes actively synthesize and accumulate cholesterol, which is a key constituent of intercellular lipid lamellae which contribute to the epidermal permeability barrier. While the pathway for cholesterol biosynthesis is established, intracellular transport mechanisms for this lipid are poorly understood, despite their importance in regulating organelle sterol content, keratinocyte differentiation status and the activity of lipid-responsive transcription factors involved in skin health, repair and disease. Recent data implicate proteins containing a steroidogenic acute regulatory protein (StAR)- related lipid transfer (START) domain in cellular cholesterol homeostasis.

AB - Terminally differentiating keratinocytes actively synthesize and accumulate cholesterol, which is a key constituent of intercellular lipid lamellae which contribute to the epidermal permeability barrier. While the pathway for cholesterol biosynthesis is established, intracellular transport mechanisms for this lipid are poorly understood, despite their importance in regulating organelle sterol content, keratinocyte differentiation status and the activity of lipid-responsive transcription factors involved in skin health, repair and disease. Recent data implicate proteins containing a steroidogenic acute regulatory protein (StAR)- related lipid transfer (START) domain in cellular cholesterol homeostasis.

KW - cholesterol homeostasis

KW - STARD4

U2 - 10.1111/j.1365-2133.2010.10102.x

DO - 10.1111/j.1365-2133.2010.10102.x

M3 - Article

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

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