Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice

Yvonne Dempsie, Ian Morecroft, David Welsh, Neil MacRitchie, Lynn Loughlin, Margaret Nilsen, Andrew Peacock, Anthony Harmar, Michael Bader, Margaret R. MacLean

Research output: Contribution to journalArticle

Abstract

The incidence of pulmonary arterial hypertension secondary to the use of indirect serotinergic agonists such as aminorex and dexfenfluramine led to the “serotonin hypothesis” of pulmonary arterial hypertension; however, the role of serotonin in dexfenfluramine-induced pulmonary arterial hypertension remains controversial. Here, we used novel transgenic mice lacking peripheral serotonin (deficient in tryptophan hydroxylase-1; Tph1-/- mice) or overexpressing the gene for the human serotonin transporter (SERT; SERT+ mice) to investigate this further.
Original languageEnglish
Pages (from-to)2928-2937
Number of pages10
JournalCirculation
Volume117
Issue number22
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Dexfenfluramine
Pulmonary Hypertension
Transgenic Mice
Serotonin
Aminorex
Serotonin Plasma Membrane Transport Proteins
Incidence
Genes

Keywords

  • pulmonary arterial hypertension
  • PAH
  • serotinergic agonists
  • serotonin
  • gene expression

Cite this

Dempsie, Yvonne ; Morecroft, Ian ; Welsh, David ; MacRitchie, Neil ; Loughlin, Lynn ; Nilsen, Margaret ; Peacock, Andrew ; Harmar, Anthony ; Bader, Michael ; MacLean, Margaret R. / Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice. In: Circulation. 2008 ; Vol. 117, No. 22. pp. 2928-2937 .
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Dempsie, Y, Morecroft, I, Welsh, D, MacRitchie, N, Loughlin, L, Nilsen, M, Peacock, A, Harmar, A, Bader, M & MacLean, MR 2008, 'Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice', Circulation, vol. 117, no. 22, pp. 2928-2937 . https://doi.org/10.1161/CIRCULATIONAHA.108.767558

Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice. / Dempsie, Yvonne; Morecroft, Ian; Welsh, David; MacRitchie, Neil; Loughlin, Lynn; Nilsen, Margaret ; Peacock, Andrew; Harmar, Anthony; Bader, Michael ; MacLean, Margaret R.

In: Circulation, Vol. 117, No. 22, 06.2008, p. 2928-2937 .

Research output: Contribution to journalArticle

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