Connexins and skin disease: insights into the role of beta connexins in skin homeostasis

Patricia E.M. Martin, Mauirce van Steensel

Research output: Contribution to journalArticle

Abstract

Cell-to-cell communication triggered by connexin channels plays a central role in maintaining epidermal homeostasis. Here, we discuss the role of the beta connexin subgroup, where site-specific mutations in at least 4 of these proteins lead to distinctive non-inflammatory and inflammatory hyperproliferative epidermal disorders.
Original languageEnglish
Pages (from-to)645-658
Number of pages14
JournalCell and Tissue Research
Volume360
Issue number3
Early online date24 Jan 2015
DOIs
Publication statusPublished - Jun 2015

Keywords

  • connexins
  • epidermis
  • gap junction

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