Connexins and skin disease: insights into the role of beta connexins in skin homeostasis

Patricia E.M. Martin, Mauirce van Steensel

Research output: Contribution to journalArticlepeer-review

Abstract

Cell-to-cell communication triggered by connexin channels plays a central role in maintaining epidermal homeostasis. Here, we discuss the role of the beta connexin subgroup, where site-specific mutations in at least 4 of these proteins lead to distinctive non-inflammatory and inflammatory hyperproliferative epidermal disorders. Recent advances in the molecular pathways evoked and correlation with clinical outcome are discussed. The latest data provide increasing evidence that connexins in the epidermis are sensors to environmental stress and that targeting aberrant hemichannel activity holds significant therapeutic potential for inflammatory skin disorders.
Original languageEnglish
Pages (from-to)645-658
Number of pages14
JournalCell and Tissue Research
Volume360
Issue number3
Early online date24 Jan 2015
DOIs
Publication statusPublished - Jun 2015

Keywords

  • connexins
  • epidermis
  • gap junction

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