Connexin43 plays diverse roles in co-ordinating cell migration and wound closure events

Research output: Contribution to journalArticle

Abstract

Chronic wounds are not only debilitating to patients, but also impose a huge financial burden on healthcare providers, as current treatments are not particularly effective. Wound healing is a highly co-ordinated process involving a vast array of signalling molecules and different cell types, therefore a substantial amount of research has been carried out in the quest to develop new therapies. The gap junction (GJ) protein connexin43 (Cx43) is one of the many molecules whose expression has been found to be up-regulated in chronic wounds and as a result targeting it may have therapeutic potential. Two different approaches have been adopted to investigate this: knockdown of Cx43 using antisense oligonucleotides and connexin mimetic peptides (CMPs) which inhibit the function of Cx43 without affecting gene expression.
Original languageEnglish
Pages (from-to)482-488
Number of pages7
JournalBiochemical Transactions
Volume43
Issue number3
DOIs
Publication statusPublished - Jun 2015

Keywords

  • cell migration
  • chronic wounds
  • connexin43

Fingerprint Dive into the research topics of 'Connexin43 plays diverse roles in co-ordinating cell migration and wound closure events'. Together they form a unique fingerprint.

  • Cite this