Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in vitro

Catherine Wright, M. A.M. Van Steensel, Malcolm B. Hodgins, Patricia E.M. Martin

Research output: Contribution to journalArticle

Abstract

Nonhealing cutaneous wounds, a major cause of morbidity and mortality, are difficult to treat. Recent studies suggest that significant increases in skin wound-healing rates occur by altering gap junction intercellular communication (GJIC). As migration of keratinocytes and fibroblasts is an important feature of wound healing, this study investigated whether migration rates in cultured normal human epidermal keratinocytes and dermal fibroblasts could be altered by modulating GJIC via connexin mimetic peptides.

Original languageEnglish
Pages (from-to)240-249
Number of pages10
JournalWound Repair and Regeneration
Volume17
Issue number2
DOIs
Publication statusPublished - 1 Apr 2009

Keywords

  • connexins
  • wound healing

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