Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in vitro

Catherine Wright; M. A.M. Van Steensel; Malcolm B. Hodgins; Patricia E.M. Martin

doi:10.1111/j.1524-475X.2009.00471.x

Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in vitro

Catherine Wright, M. A.M. Van Steensel, Malcolm B. Hodgins, Patricia E.M. Martin

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Nonhealing cutaneous wounds, a major cause of morbidity and mortality, are difficult to treat. Recent studies suggest that significant increases in skin wound-healing rates occur by altering gap junction intercellular communication (GJIC). As migration of keratinocytes and fibroblasts is an important feature of wound healing, this study investigated whether migration rates in cultured normal human epidermal keratinocytes and dermal fibroblasts could be altered by modulating GJIC via connexin mimetic peptides.

Original language	English
Pages (from-to)	240-249
Number of pages	10
Journal	Wound Repair and Regeneration
Volume	17
Issue number	2
DOIs	https://doi.org/10.1111/j.1524-475X.2009.00471.x
Publication status	Published - 1 Apr 2009

Keywords

connexins
wound healing

Documents and Links

10.1111/j.1524-475X.2009.00471.x

http://researchonline.gcu.ac.uk/sls/289

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title = "Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in vitro",

abstract = "Nonhealing cutaneous wounds, a major cause of morbidity and mortality, are difficult to treat. Recent studies suggest that significant increases in skin wound-healing rates occur by altering gap junction intercellular communication (GJIC). As migration of keratinocytes and fibroblasts is an important feature of wound healing, this study investigated whether migration rates in cultured normal human epidermal keratinocytes and dermal fibroblasts could be altered by modulating GJIC via connexin mimetic peptides.",

keywords = "connexins, wound healing",

author = "Catherine Wright and {Van Steensel}, {M. A.M.} and Hodgins, {Malcolm B.} and Martin, {Patricia E.M.}",

note = "Originally published in: Wound Repair and Regeneration (2009), 17 (2), pp.240-249.",

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T1 - Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in vitro

AU - Wright, Catherine

AU - Van Steensel, M. A.M.

AU - Hodgins, Malcolm B.

AU - Martin, Patricia E.M.

N1 - Originally published in: Wound Repair and Regeneration (2009), 17 (2), pp.240-249.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Nonhealing cutaneous wounds, a major cause of morbidity and mortality, are difficult to treat. Recent studies suggest that significant increases in skin wound-healing rates occur by altering gap junction intercellular communication (GJIC). As migration of keratinocytes and fibroblasts is an important feature of wound healing, this study investigated whether migration rates in cultured normal human epidermal keratinocytes and dermal fibroblasts could be altered by modulating GJIC via connexin mimetic peptides.

AB - Nonhealing cutaneous wounds, a major cause of morbidity and mortality, are difficult to treat. Recent studies suggest that significant increases in skin wound-healing rates occur by altering gap junction intercellular communication (GJIC). As migration of keratinocytes and fibroblasts is an important feature of wound healing, this study investigated whether migration rates in cultured normal human epidermal keratinocytes and dermal fibroblasts could be altered by modulating GJIC via connexin mimetic peptides.

KW - connexins

KW - wound healing

U2 - 10.1111/j.1524-475X.2009.00471.x

DO - 10.1111/j.1524-475X.2009.00471.x

M3 - Article

VL - 17

SP - 240

EP - 249

JO - Wound Repair and Regeneration

JF - Wound Repair and Regeneration

SN - 1067-1927

IS - 2

ER -