Connexin-mediated regulation of the pulmonary vasculature

Research output: Contribution to journalArticlepeer-review


Pulmonary arterial hypertension (PAH) is a complex, multi-factorial disorder characterized by both constriction and remodelling of the distal pulmonary vasculature. This leads to increased pulmonary pressures and eventually right heart failure. Current drugs, which primarily target the vasoconstriction, serve only to prolong life and novel therapies targeting both the vasoconstriction and the remodelling are required. Aberrant signalling between cells of the pulmonary vasculature has been associated with the development of PAH. In particular, endothelial dysfunction can lead to hyperplasia of the underlying medial layer.
Original languageEnglish
Pages (from-to)524-529
Number of pages6
JournalBiochemical Transactions
Issue number3
Publication statusPublished - Jun 2015


  • pulmonary arterial hypertension
  • pulmonary vasculature
  • heart failure

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