Connexin-mediated regulation of the pulmonary vasculature

Research output: Contribution to journalArticlepeer-review

Abstract

Pulmonary arterial hypertension (PAH) is a complex, multi-factorial disorder characterized by both constriction and remodelling of the distal pulmonary vasculature. This leads to increased pulmonary pressures and eventually right heart failure. Current drugs, which primarily target the vasoconstriction, serve only to prolong life and novel therapies targeting both the vasoconstriction and the remodelling are required. Aberrant signalling between cells of the pulmonary vasculature has been associated with the development of PAH. In particular, endothelial dysfunction can lead to hyperplasia of the underlying medial layer. Connexins are a family of transmembrane proteins which can form intercellular communication channels known as gap junctions. This review will discuss recent evidence which shows that connexins play a role in regulation of the pulmonary vasculature and that dysregulation of connexins may contribute to PAH pathogenesis. Interaction of connexins with signalling pathways relevant to the pathogenesis of PAH, such as bone morphogenetic protein (BMP), serotonin and oestrogen are discussed.
Original languageEnglish
Pages (from-to)524-529
Number of pages6
JournalBiochemical Transactions
Volume43
Issue number3
DOIs
Publication statusPublished - 1 Jun 2015

Keywords

  • Bone morphogenetic protein receptor type II
  • Connexin
  • Gap junction
  • Pulmonary arterial hypertension
  • Pulmonary vasculature
  • Serotonin

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