Connexin communication compartments and wound repair in epithelial tissue

Marc Chanson, Masakatsu Watanabe, Erin M. O'Shaughnessy, Alice Zoso, Patricia E. Martin

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)
72 Downloads (Pure)


Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they must rapidly repair to maintain cellular homeostasis. These tissue networks, that range from a single cell layer, such as in airway epithelium, to highly stratified and differentiated epithelial surfaces, such as the epidermis, are held together by a junctional nexus of proteins including adherens, tight and gap junctions, often forming unique and localised communication compartments activated for localised tissue repair. This review focuses on the dynamic changes that occur in connexins, the constituent proteins of the intercellular gap junction channel, during wound-healing processes and in localised inflammation, with an emphasis on the lung and skin. Current developments in targeting connexins as corrective therapies to improve wound closure and resolve localised inflammation are also discussed. Finally, we consider the emergence of the zebrafish as a concerted whole-animal model to study, visualise and track the events of wound repair and regeneration in real-time living model systems
Original languageEnglish
Article number1354
Pages (from-to)1354
JournalInternational Journal of Molecular Sciences
Issue number5
Publication statusPublished - 3 May 2018


  • connexin
  • wound repair
  • wound healing
  • pannexin
  • inflammation
  • epithelial tissue
  • zebrafish models
  • epithelium/metabolism
  • wound healing/physiology
  • zebrafish
  • gap junctions/metabolism
  • animals
  • connexins/metabolism

ASJC Scopus subject areas

  • Molecular Biology
  • Spectroscopy
  • Catalysis
  • Inorganic Chemistry
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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