Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells

Simone Pollok; Ann-Catherine Pfeiffer; Ralf Lobmann; Catherine S. Wright; Ingrid Moll; Patricia E.M. Martin; Johanna M. Brandner

doi:10.1111/j.1582-4934.2010.01057.x

Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells

Simone Pollok, Ann-Catherine Pfeiffer, Ralf Lobmann, Catherine S. Wright, Ingrid Moll, Patricia E.M. Martin, Johanna M. Brandner

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

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Abstract

During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.

Original language	English
Pages (from-to)	861–873
Number of pages	13
Journal	Journal of Cellular and Molecular Medicine
Volume	15
Issue number	4
DOIs	https://doi.org/10.1111/j.1582-4934.2010.01057.x
Publication status	Published - Apr 2011

Keywords

connexins
gap junctions
wound healing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1582-4934.2010.01057.x

Pollok, S. (2011) Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells
This is the final publisher version of the article originally published in: Journal of Cellular and Molecular Medicine. The article is available at: https://doi.org/10.1111/j.1582-4934.2010.01057.x. Copyright © The Author(s).
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Cite this

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title = "Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells",

abstract = "During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.",

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AU - Pollok, Simone

AU - Pfeiffer, Ann-Catherine

AU - Lobmann, Ralf

AU - Wright, Catherine S.

AU - Moll, Ingrid

AU - Martin, Patricia E.M.

AU - Brandner, Johanna M.

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PY - 2011/4

Y1 - 2011/4

N2 - During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.

AB - During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.

KW - connexins

KW - gap junctions

KW - wound healing

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EP - 873

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

SN - 1582-1838

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ER -

Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells

Abstract

Keywords

UN SDGs

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