Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells

Simone Pollok; Ann-Catherine Pfeiffer; Ralf Lobmann; Catherine Wright; Ingrid Moll; Patricia E.M. Martin; Johanna M. Brandner

doi:10.1111/j.1582-4934.2010.01057.x

Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells

Simone Pollok, Ann-Catherine Pfeiffer, Ralf Lobmann, Catherine Wright, Ingrid Moll, Patricia E.M. Martin, Johanna M. Brandner

Biological and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.

Original language	English
Pages (from-to)	861–873
Number of pages	13
Journal	Journal of Cellular and Molecular Medicine
Volume	15
Issue number	4
DOIs	https://doi.org/10.1111/j.1582-4934.2010.01057.x
Publication status	Published - Mar 2010

Keywords

connexins
gap junctions
wound healing

Documents and Links

10.1111/j.1582-4934.2010.01057.x

Publication in Scopus

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title = "Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells",

abstract = "During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.",

keywords = "connexins, gap junctions, wound healing",

author = "Simone Pollok and Ann-Catherine Pfeiffer and Ralf Lobmann and Catherine Wright and Ingrid Moll and Martin, {Patricia E.M.} and Brandner, {Johanna M.}",

year = "2010",

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language = "English",

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journal = "Journal of Cellular and Molecular Medicine",

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Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells. / Pollok, Simone; Pfeiffer, Ann-Catherine; Lobmann, Ralf; Wright, Catherine; Moll, Ingrid; Martin, Patricia E.M.; Brandner, Johanna M.

In: Journal of Cellular and Molecular Medicine, Vol. 15, No. 4, 03.2010, p. 861–873.

Research output: Contribution to journal › Article › peer-review

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AU - Pollok, Simone

AU - Pfeiffer, Ann-Catherine

AU - Lobmann, Ralf

AU - Wright, Catherine

AU - Moll, Ingrid

AU - Martin, Patricia E.M.

AU - Brandner, Johanna M.

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AB - During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.

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