During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.
- gap junctions
- wound healing