Abstract
During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.
| Original language | English |
|---|---|
| Pages (from-to) | 861–873 |
| Number of pages | 13 |
| Journal | Journal of Cellular and Molecular Medicine |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Mar 2010 |
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Keywords
- connexins
- gap junctions
- wound healing
Cite this
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Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells. / Pollok, Simone; Pfeiffer, Ann-Catherine; Lobmann, Ralf; Wright, Catherine; Moll, Ingrid; Martin, Patricia E.M.; Brandner, Johanna M.
In: Journal of Cellular and Molecular Medicine, Vol. 15, No. 4, 03.2010, p. 861–873.Research output: Contribution to journal › Article
TY - JOUR
T1 - Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells
AU - Pollok, Simone
AU - Pfeiffer, Ann-Catherine
AU - Lobmann, Ralf
AU - Wright, Catherine
AU - Moll, Ingrid
AU - Martin, Patricia E.M.
AU - Brandner, Johanna M.
PY - 2010/3
Y1 - 2010/3
N2 - During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.
AB - During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.
KW - connexins
KW - gap junctions
KW - wound healing
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-78649739295&partnerID=8YFLogxK
U2 - 10.1111/j.1582-4934.2010.01057.x
DO - 10.1111/j.1582-4934.2010.01057.x
M3 - Article
VL - 15
SP - 861
EP - 873
JO - Journal of Cellular and Molecular Medicine
JF - Journal of Cellular and Molecular Medicine
SN - 1582-1838
IS - 4
ER -