Connexin 43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells

Simone Pollok, Ann-Catherine Pfeiffer, Ralf Lobmann, Catherine Wright, Ingrid Moll, Patricia E.M. Martin, Johanna M. Brandner

Research output: Contribution to journalArticle

Abstract

During early wound healing (WH) events Connexin 43 (Cx43) is downregulated at wound margins. In chronic wound margins, including diabetic wounds, Cx43 expression is enhanced suggesting that downregulation is important for WH. We previously reported that the Cx43 mimetic peptide Gap27 blocks Cx43 mediated intercellular communication and promotes skin cell migration of infant cells in vitro. In the present work we further investigated the molecular mechanism of Gap27 action and its therapeutic potential to improve WH in skin tissue and diabetic and non-diabetic cells.

Original languageEnglish
Pages (from-to)861–873
Number of pages13
JournalJournal of Cellular and Molecular Medicine
Volume15
Issue number4
DOIs
Publication statusPublished - Mar 2010

Keywords

  • connexins
  • gap junctions
  • wound healing

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