Concurrent investigation of global motion and form processing in amblyopia: an equivalent noise approach

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Abstract

Purpose: Directly comparing the motion and form processing in neurologic disorders has remained difficult due to the limitations in the experimental stimulus. In the current study, motion and form processing in amblyopia was characterized using random dot stimuli in different noise levels to parse out the effect of local and global processing on motion and form perception.Methods: A total of 17 amblyopes (8 anisometropic and 9 strabismic), and 12 visually normal subjects monocularly estimated the global direction of motion and global orientation in random dot kinematograms (RDK) and Glass patterns (Glass), whose directions/orientations were drawn from normal distributions with a range of means and variances that served as external noise. Direction/orientation discrimination thresholds were measured without noise first then variance threshold was measured at the multiples of the direction/orientation threshold. The direction/orientation and variance thresholds were modelled to estimate internal noise and sampling efficiency parameters.Results: Overall, the thresholds for Glass were higher than RDK for all subjects. The thresholds for both Glass and RDK were higher in the strabismic eyes compared with the fellow and normal eyes. On the other hand, the thresholds for anisometropic amblyopic eyes were similar to the normal eyes. The worse performance of strabismic amblyopes was best explained by relatively low sampling efficiency compared with other groups (P < 0.05).Conclusions: A deficit in global motion and form perception was only evident in strabismic amblyopia. Contrary to the dorsal stream deficiency hypothesis assumed in other developmental disorders, deficits were present in both motion (dorsal) and form (ventral) processing.
Original languageEnglish
Pages (from-to)5015-5022
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume57
Issue number11
Early online date30 Sep 2016
DOIs
Publication statusPublished - Sep 2016

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Amblyopia
Glass
Noise
Form Perception
Motion Perception
Normal Distribution
Nervous System Diseases
Direction compound

Keywords

  • vision sciences
  • amblyopia
  • ophthalmology

Cite this

@article{b4352f6f3fcf4a0ca0d90935cfe14822,
title = "Concurrent investigation of global motion and form processing in amblyopia: an equivalent noise approach",
abstract = "Purpose: Directly comparing the motion and form processing in neurologic disorders has remained difficult due to the limitations in the experimental stimulus. In the current study, motion and form processing in amblyopia was characterized using random dot stimuli in different noise levels to parse out the effect of local and global processing on motion and form perception.Methods: A total of 17 amblyopes (8 anisometropic and 9 strabismic), and 12 visually normal subjects monocularly estimated the global direction of motion and global orientation in random dot kinematograms (RDK) and Glass patterns (Glass), whose directions/orientations were drawn from normal distributions with a range of means and variances that served as external noise. Direction/orientation discrimination thresholds were measured without noise first then variance threshold was measured at the multiples of the direction/orientation threshold. The direction/orientation and variance thresholds were modelled to estimate internal noise and sampling efficiency parameters.Results: Overall, the thresholds for Glass were higher than RDK for all subjects. The thresholds for both Glass and RDK were higher in the strabismic eyes compared with the fellow and normal eyes. On the other hand, the thresholds for anisometropic amblyopic eyes were similar to the normal eyes. The worse performance of strabismic amblyopes was best explained by relatively low sampling efficiency compared with other groups (P < 0.05).Conclusions: A deficit in global motion and form perception was only evident in strabismic amblyopia. Contrary to the dorsal stream deficiency hypothesis assumed in other developmental disorders, deficits were present in both motion (dorsal) and form (ventral) processing.",
keywords = "vision sciences, amblyopia, ophthalmology",
author = "Joshi, {Mahesh R.} and Simmers, {Anita J.} and Jeon, {Seong T.}",
note = "Acceptance date from VoR OA journal since Jan 2016: http://iovs.arvojournals.org/ss/about.aspx Earliest pub date - used 30-9-16 (Sept 2016 is date given on journal webpage) Applied Gold exception as published in OA journal (will be immediate OA). ET 19/12/19",
year = "2016",
month = "9",
doi = "10.1167/iovs.15-18609",
language = "English",
volume = "57",
pages = "5015--5022",
journal = "Investigative Ophthalmology & Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology (ARVO)",
number = "11",

}

TY - JOUR

T1 - Concurrent investigation of global motion and form processing in amblyopia: an equivalent noise approach

AU - Joshi, Mahesh R.

AU - Simmers, Anita J.

AU - Jeon, Seong T.

N1 - Acceptance date from VoR OA journal since Jan 2016: http://iovs.arvojournals.org/ss/about.aspx Earliest pub date - used 30-9-16 (Sept 2016 is date given on journal webpage) Applied Gold exception as published in OA journal (will be immediate OA). ET 19/12/19

PY - 2016/9

Y1 - 2016/9

N2 - Purpose: Directly comparing the motion and form processing in neurologic disorders has remained difficult due to the limitations in the experimental stimulus. In the current study, motion and form processing in amblyopia was characterized using random dot stimuli in different noise levels to parse out the effect of local and global processing on motion and form perception.Methods: A total of 17 amblyopes (8 anisometropic and 9 strabismic), and 12 visually normal subjects monocularly estimated the global direction of motion and global orientation in random dot kinematograms (RDK) and Glass patterns (Glass), whose directions/orientations were drawn from normal distributions with a range of means and variances that served as external noise. Direction/orientation discrimination thresholds were measured without noise first then variance threshold was measured at the multiples of the direction/orientation threshold. The direction/orientation and variance thresholds were modelled to estimate internal noise and sampling efficiency parameters.Results: Overall, the thresholds for Glass were higher than RDK for all subjects. The thresholds for both Glass and RDK were higher in the strabismic eyes compared with the fellow and normal eyes. On the other hand, the thresholds for anisometropic amblyopic eyes were similar to the normal eyes. The worse performance of strabismic amblyopes was best explained by relatively low sampling efficiency compared with other groups (P < 0.05).Conclusions: A deficit in global motion and form perception was only evident in strabismic amblyopia. Contrary to the dorsal stream deficiency hypothesis assumed in other developmental disorders, deficits were present in both motion (dorsal) and form (ventral) processing.

AB - Purpose: Directly comparing the motion and form processing in neurologic disorders has remained difficult due to the limitations in the experimental stimulus. In the current study, motion and form processing in amblyopia was characterized using random dot stimuli in different noise levels to parse out the effect of local and global processing on motion and form perception.Methods: A total of 17 amblyopes (8 anisometropic and 9 strabismic), and 12 visually normal subjects monocularly estimated the global direction of motion and global orientation in random dot kinematograms (RDK) and Glass patterns (Glass), whose directions/orientations were drawn from normal distributions with a range of means and variances that served as external noise. Direction/orientation discrimination thresholds were measured without noise first then variance threshold was measured at the multiples of the direction/orientation threshold. The direction/orientation and variance thresholds were modelled to estimate internal noise and sampling efficiency parameters.Results: Overall, the thresholds for Glass were higher than RDK for all subjects. The thresholds for both Glass and RDK were higher in the strabismic eyes compared with the fellow and normal eyes. On the other hand, the thresholds for anisometropic amblyopic eyes were similar to the normal eyes. The worse performance of strabismic amblyopes was best explained by relatively low sampling efficiency compared with other groups (P < 0.05).Conclusions: A deficit in global motion and form perception was only evident in strabismic amblyopia. Contrary to the dorsal stream deficiency hypothesis assumed in other developmental disorders, deficits were present in both motion (dorsal) and form (ventral) processing.

KW - vision sciences

KW - amblyopia

KW - ophthalmology

U2 - 10.1167/iovs.15-18609

DO - 10.1167/iovs.15-18609

M3 - Article

VL - 57

SP - 5015

EP - 5022

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

SN - 0146-0404

IS - 11

ER -