Compositional analyses of the associations between sedentary time, different intensities of physical activity, and cardiometabolic biomarkers among children and youth from the United States

Valerie Carson*, Mark S. Tremblay, Jean-Philippe Chaput, Duncan McGregor, Sebastien Chastin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
140 Downloads (Pure)

Abstract

Introduction
Compositional data analysis is one appropriate method for co-dependent data, even when
data are collected for a subdivision of the 24-hour period, such as the waking day. Objec-
tives were to use compositional analyses to examine the combined and relative associations
of sedentary time (ST), light-intensity physical activity (LPA), moderate-intensity physical
activity (MPA), and vigorous-intensity physical activity (VPA) with cardiometabolic biomark-
ers in a representative sample of children and youth.
Methods
This cross-sectional study included 2544 participants aged 6–17 years from the 2003–2006
United States National Health and Nutrition Examination Survey. ST (<100 counts per min-
ute), LPA (100 counts per minute to <4 METs; Freedson age-specific equation), MPA (4 to
<7 METs), and VPA (�7 METs) were accelerometer-derived. Cardiometabolic biomarkers
included waist circumference, body mass index (BMI) z-score, HDL-cholesterol, C-reactive
protein, and blood pressure. Triglycerides, glucose, insulin, and LDL-cholesterol were mea-
sured in a fasting sub-sample of adolescents (n = 670). Compositional linear regression
models were conducted.
Results
The composition of ST, LPA, MPA, and VPA was significantly associated with BMI z-score,
log waist circumference, systolic and diastolic blood pressure, HDL-cholesterol, and log
plasma glucose (variance explained: 1–29%). Relative to the other three behaviors, VPA
was negatively associated with BMI z-score (γVPA = -0.206, p = 0.005) and waist circumference (γVPA = -0.03, p = 0.001). Conversely, ST was positively associated with
waist circumference (γST = 0.029, p = 0.013). ST and VPA were also positively associated
with diastolic blood pressure (γST = 2.700, p = 0.018; γVPA = 1.246, p = 0.038), relative to
the other behaviors, whereas negative associations were observed for LPA (γLPA = -2.892,
p = 0.026). Finally, VPA was positively associated with HDL-cholesterol, relative to other
behaviors (γVPA = 0.058, p<0.001).
Conclusions
The ST and physical activity composition appears important for many aspects of cardiome-
tabolic health in children and youth. Compositions with more time in higher-intensity activi-
ties may be better for some aspects of cardiometabolic health
Original languageEnglish
Article numbere0220009
Number of pages14
JournalPLoS ONE
Volume14
Issue number7
DOIs
Publication statusPublished - 22 Jul 2019

Keywords

  • compositional data analysis
  • physical actitvity
  • cardiometabolic biomarkers

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • General
  • Biochemistry, Genetics and Molecular Biology(all)

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