Complement Factor H Y402H polymorphism is not associated with late-onset Azheimer’s disease

Gillian Hunter, Petra Proitsi, Julie Williams, Michael O'Donovan, Michael Owen, John Powell, Simon Lovestone

Research output: Contribution to journalArticle

Abstract

There is evidence to suggest a role for immune dysfunction in the pathogenesis of Alzheimer's disease, and it has previously been shown that blood plasma levels of the protein complement factor H, a member of the alternative complement pathway, was specifically elevated in people with late-onset Alzheimer's disease. We have genotyped the common complement factor H Y402H polymorphism in a large case-control cohort to investigate association with late-onset Alzheimer's disease susceptibility and find no evidence that this SNP is associated with disease risk. However, it remains possible that another variant in this gene may modify susceptibility for late-onset Alzheimer's disease.
Original languageEnglish
Pages (from-to)331-4
Number of pages4
JournalNeuromolecular Medicine
Volume9
Issue number4
Early online date22 Sep 2007
DOIs
Publication statusPublished - Dec 2007

Keywords

  • late-onset Alzheimer's disease
  • complement factor H
  • association study
  • age-related macular degeneration

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